Molecular Pharmacology of Cardiac Ion Channels

Marban, Eduardo

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL052768-03
• Application #: 2230364
• Study Section: Pharmacology A Study Section (PHRA)
• Project Start: 1994-08-01
• Project End: 1999-07-31
• Budget Start: 1996-08-01
• Budget End: 1997-07-31
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Johns Hopkins University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 045911138
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Yamagishi, Toshio; Xiong, Wei; Kondratiev, Andre et al. (2009) Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding. Mol Pharmacol 76:861-71

Azene, Ezana M; Sang, Dongpei; Tsang, Suk-Ying et al. (2005) Pore-to-gate coupling of HCN channels revealed by a pore variant that contributes to gating but not permeation. Biochem Biophys Res Commun 327:1131-42

Azene, Ezana M; Xue, Tian; Marban, Eduardo et al. (2005) Non-equilibrium behavior of HCN channels: insights into the role of HCN channels in native and engineered pacemakers. Cardiovasc Res 67:263-73

Tsang, Suk Ying; Tsushima, Robert G; Tomaselli, Gordon F et al. (2005) A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Mol Pharmacol 67:424-34

Moore, Jennifer C; van Laake, Linda W; Braam, Stefan R et al. (2005) Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies. Reprod Toxicol 20:377-91

Wang, Kai; Xue, Tian; Tsang, Suk-Ying et al. (2005) Electrophysiological properties of pluripotent human and mouse embryonic stem cells. Stem Cells 23:1526-34

Xue, Tian; Cho, Hee Cheol; Akar, Fadi G et al. (2005) Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 111:11-20

Li, Ronald A; Tomaselli, Gordon F (2004) Using the deadly mu-conotoxins as probes of voltage-gated sodium channels. Toxicon 44:117-22

Tsang, Suk Ying; Lesso, Heinte; Li, Ronald A (2004) Critical intra-linker interactions of HCN1-encoded pacemaker channels revealed by interchange of S3-S4 determinants. Biochem Biophys Res Commun 322:652-8

Xue, Tian; Ennis, Irene L; Sato, Kazuki et al. (2003) Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry. Biophys J 85:2299-310