This is a competitive renewal of an R29 award in which the Principal Investigator has found that inhibition of complement with C-1 esterase inhibitor or soluble complement receptor type I has consistently attenuated I/R injury in animals. In the R29 portion of the preliminary work, the Principal Investigator has demonstrated that specific inhibition of C5a or inhibition of C5a and C5b-9 also decrease infarct size, neutrophil infiltration and apoptosis following myocardial I/R. The PI notes that myocardial vascular endothelium appears to be the site of initial complement activation during reperfusion. The global goal of the current investigations is to delineate the role of complement in myocardial I/R injury and to characterize the molecular mechanisms of complement activation during myocardial I/R.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052886-07
Application #
6389384
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Massicot-Fisher, Judith
Project Start
1995-08-01
Project End
2003-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
7
Fiscal Year
2001
Total Cost
$403,468
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
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