The major objectives of this study are to determine: a) the role of visceral (intraabdominal) fat independent of total fat in determining risk factors for coronary heart disease (CHD) and type 2 diabetes mellitus (DM), and how this may differ by race and by gender; and b) race/gender differences in resting energy expenditure (REE) and the relationship of REE to adiposity and longitudinal change in adiposity. A 5-year follow-up examination including REE and the CT measurement of visceral fat will be performed in a biracial (white and black men and women) study group of 320 participants from the Oakland and Birmingham clinical centers of the Coronary Artery Risk Development in Young Adults (CARDIA) study, representing 80 percent of the participants who underwent these assessments at a baseline exam in 1995-96 conducted in conjunction with their CARDIA study examination. The CARDIA examination conducted in conjunction with this 5-year follow-up examination will provide funding for cardiovascular risk factor measurements including blood pressure, lipids, and anthropometry. The major hypotheses (specific aims) to be tested in the next funding period are: 1) For a given 5-year change in overall body fat, black men will have a smaller change in visceral fat than white men, but there will be no difference in visceral fat change between black women and white women; 2) Change in visceral fat will be more highly correlated with change in CHD risk factors than change in most other measures of adiposity in all race/gender groups. However, change in visceral fat and change in waist circumference will have similar correlations to CHD risk factor change, providing support for the use of waist circumference as a reasonably adequate surrogate for CT-assessed visceral fat; and 3) Baseline mean REE (adjusted for body composition) and change in physical activity will be associated with change in body composition. This study will provide information regarding racial differences in disease risk associated with body composition and fat distribution, a research priority highlighted by the recently released report of the NHLBI Obesity Education Task Force.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053359-05
Application #
6184042
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1995-09-01
Project End
2003-03-31
Budget Start
2000-06-07
Budget End
2001-03-31
Support Year
5
Fiscal Year
2000
Total Cost
$742,387
Indirect Cost
Name
Kaiser Foundation Hospitals
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94612
Zhi, Degui; Shendre, Aditi; Scherzer, Rebecca et al. (2015) Deep sequencing of RYR3 gene identifies rare and common variants associated with increased carotid intima-media thickness (cIMT) in HIV-infected individuals. J Hum Genet 60:63-7
Manenschijn, Laura; Scherzer, Rebecca; Koper, Jan W et al. (2014) Association of glucocorticoid receptor haplotypes with body composition and metabolic parameters in HIV-infected patients from the FRAM study. Pharmacogenet Genomics 24:156-61
Wheeler, Amber L; Scherzer, Rebecca; Lee, Daniel et al. (2014) HIV/hepatitis C virus coinfection ameliorates the atherogenic lipoprotein abnormalities of HIV infection. AIDS 28:49-58
Shen, Wei; Scherzer, Rebecca; Gantz, Madeleine et al. (2012) Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants: the CARDIA study. J Clin Endocrinol Metab 97:1337-46
Eastburn, Abigail; Scherzer, Rebecca; Zolopa, Andrew R et al. (2011) Association of low level viremia with inflammation and mortality in HIV-infected adults. PLoS One 6:e26320
Kosmiski, Lisa A; Scherzer, Rebecca; Heymsfield, Steven B et al. (2011) Association of increased upper trunk and decreased leg fat with 2-h glucose in control and HIV-infected persons. Diabetes Care 34:2448-53
Irvin, Marguerite Ryan; Shrestha, Sadeep; Chen, Yii-Der I et al. (2011) Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men. Pharmacogenet Genomics 21:798-807
Scherzer, Rebecca; Heymsfield, Steven B; Lee, Daniel et al. (2011) Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection. AIDS 25:1405-14
Yarasheski, Kevin E; Scherzer, Rebecca; Kotler, Donald P et al. (2011) Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals. J Gerontol A Biol Sci Med Sci 66:332-40
Lake, Jordan E; Wohl, David; Scherzer, Rebecca et al. (2011) Regional fat deposition and cardiovascular risk in HIV infection: the FRAM study. AIDS Care 23:929-38

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