Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL053455-01A2
Application #
2231388
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Project Start
1996-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Yu, Ying-Chun; Miki, Haruna; Nakamura, Yumi et al. (2011) Curcumin and genistein additively potentiate G551D-CFTR. J Cyst Fibros 10:243-52
Jih, Kang-Yang; Li, Min; Hwang, Tzyh-Chang et al. (2011) The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR. J Physiol 589:2719-31
Bai, Yonghong; Li, Min; Hwang, Tzyh-Chang (2010) Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation. J Gen Physiol 136:293-309
Kopeikin, Zoia; Sohma, Yoshiro; Li, Min et al. (2010) On the mechanism of CFTR inhibition by a thiazolidinone derivative. J Gen Physiol 136:659-71
Miki, Haruna; Zhou, Zhen; Li, Min et al. (2010) Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs. J Biol Chem 285:19967-75
Tsai, Ming-Feng; Shimizu, Hiroyasu; Sohma, Yoshiro et al. (2009) State-dependent modulation of CFTR gating by pyrophosphate. J Gen Physiol 133:405-19
Abbey, Craig K; Eckstein, Miguel P (2009) Frequency tuning of perceptual templates changes with noise magnitude. J Opt Soc Am A Opt Image Sci Vis 26:B72-83
Wang, Xiaohui; Bompadre, Silvia G; Li, Min et al. (2009) Mutations at the signature sequence of CFTR create a Cd(2+)-gated chloride channel. J Gen Physiol 133:69-77
Bompadre, Silvia G; Li, Min; Hwang, Tzyh-Chang (2008) Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog. J Biol Chem 283:5364-9
Bompadre, Silvia G; Sohma, Yoshiro; Li, Min et al. (2007) G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects. J Gen Physiol 129:285-98

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