Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053541-02
Application #
2231520
Study Section
Special Emphasis Panel (ZRG4-CVB (03))
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Fukuta, Hidekatsu; Little, William C (2008) The cardiac cycle and the physiologic basis of left ventricular contraction, ejection, relaxation, and filling. Heart Fail Clin 4:1-11
Tachibana, Hideo; Cheng, Heng-Jie; Ukai, Tomohiko et al. (2005) Levosimendan improves LV systolic and diastolic performance at rest and during exercise after heart failure. Am J Physiol Heart Circ Physiol 288:H914-22
Zhang, Zhu-Shan; Cheng, Heng-Jie; Onishi, Katsuya et al. (2005) Enhanced inhibition of L-type Ca2+ current by beta3-adrenergic stimulation in failing rat heart. J Pharmacol Exp Ther 315:1203-11
Morimoto, Atsushi; Hasegawa, Hiroshi; Cheng, Heng-Jie et al. (2004) Endogenous beta3-adrenoreceptor activation contributes to left ventricular and cardiomyocyte dysfunction in heart failure. Am J Physiol Heart Circ Physiol 286:H2425-33
Hasegawa, Hiroshi; Little, William C; Ohno, Michiya et al. (2003) Diastolic mitral annular velocity during the development of heart failure. J Am Coll Cardiol 41:1590-7
Ohte, Nobuyuki; Cheng, Che-Ping; Little, William C (2003) Tachycardia exacerbates abnormal left ventricular-arterial coupling in heart failure. Heart Vessels 18:136-41
Ukai, T; Cheng, C P; Tachibana, H et al. (2001) Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure. Circulation 103:750-5
Cheng, C P; Ukai, T; Onishi, K et al. (2001) The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure. Am J Physiol Heart Circ Physiol 280:H1853-60
Cheng, H J; Zhang, Z S; Onishi, K et al. (2001) Upregulation of functional beta(3)-adrenergic receptor in the failing canine myocardium. Circ Res 89:599-606
Little, W C; Kitzman, D W; Cheng, C P (2000) Diastolic dysfunction as a cause of exercise intolerance. Heart Fail Rev 5:301-6

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