Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053557-02
Application #
2231542
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1994-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
McLaughlin, Patricia J (2002) Exposure to the opioid antagonist naltrexone throughout gestation alters postnatal heart development. Biol Neonate 82:207-16
Zagon, I S; Wu, Y; McLaughlin, P J (1999) Opioid growth factor and organ development in rat and human embryos. Brain Res 839:313-22
McLaughlin, P J; Wu, Y (1998) Opioid gene expression in the developing and adult rat heart. Dev Dyn 211:153-63
Wu, Y; McLaughlin, P J; Zagon, I S (1998) Ontogeny of the opioid growth factor, [Met5]-enkephalin, preproenkephalin gene expression, and the zeta opioid receptor in the developing and adult aorta of rat. Dev Dyn 211:327-37
Wilson, R P; McLaughlin, P J; Lang, C M et al. (1998) Temporal variation in cellular proliferation during recornification of mouse tail skin. Cell Prolif 31:191-201
Zagon, I S; Tobias, S W; Hytrek, S D et al. (1998) Opioid receptor blockade throughout prenatal life confers long-term insensitivity to morphine and alters mu opioid receptors. Pharmacol Biochem Behav 59:201-7
Zagon, I S; Hurst, W J; McLaughlin, P J (1998) Naltrexone is not detected in preweaning rats following transplacental exposure: implications for growth modulation. Life Sci 62:221-8
McLaughlin, P J; Allar, M A (1998) Preproenkephalin gene expression and [Met5]-enkephalin levels in the developing rat heart. Brain Res Mol Brain Res 60:160-7
McLaughlin, P J; Tobias, S W; Lang, C M et al. (1997) Opioid receptor blockade during prenatal life modifies postnatal behavioral development. Pharmacol Biochem Behav 58:1075-82
Zagon, I S; Hytrek, S D; Smith, J P et al. (1997) Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice. Cancer Lett 112:167-75

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