Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053777-03
Application #
2231881
Study Section
Special Emphasis Panel (ZHL1-CSR-K (S1))
Project Start
1994-09-30
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Komiyama, Tomoko; VanderLugt, Bryan; Fugere, Martin et al. (2003) Optimization of protease-inhibitor interactions by randomizing adventitious contacts. Proc Natl Acad Sci U S A 100:8205-10
Arnold, S M; Fessler, L I; Fessler, J H et al. (2000) Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Biochemistry 39:2149-63
Pipe, S W; Morris, J A; Shah, J et al. (1998) Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. J Biol Chem 273:8537-44
Amano, K; Michnick, D A; Moussalli, M et al. (1998) Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test. Thromb Haemost 79:557-63
Bendetowicz, A V; Morris, J A; Wise, R J et al. (1998) Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers. Blood 92:529-38
Welihinda, A A; Tirasophon, W; Green, S R et al. (1998) Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol 18:1967-77
Amano, K; Sarkar, R; Pemberton, S et al. (1998) The molecular basis for cross-reacting material-positive hemophilia A due to missense mutations within the A2-domain of factor VIII. Blood 91:538-48
Rosenberg, J B; Foster, P A; Kaufman, R J et al. (1998) Intracellular trafficking of factor VIII to von Willebrand factor storage granules. J Clin Invest 101:613-24
Swaroop, M; Moussalli, M; Pipe, S W et al. (1997) Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII. J Biol Chem 272:24121-4
Kaufman, R J; Pipe, S W; Tagliavacca, L et al. (1997) Biosynthesis, assembly and secretion of coagulation factor VIII. Blood Coagul Fibrinolysis 8 Suppl 2:S3-14

Showing the most recent 10 out of 12 publications