Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054038-03
Application #
2232228
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Giovino, Maria A; Wang, Hui; Sykes, Megan et al. (2005) Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures. Exp Hematol 33:363-70
Lan, Ping; Wang, Lan; Diouf, Bintou et al. (2004) Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood 103:3964-9
Eguchi, Hiroshi; Knosalla, Christoph; Lan, Ping et al. (2004) T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model. Transplantation 78:1609-17
Le Guern, Annie C; Giovino, Maria A; Abe, Masahiro et al. (2003) Stem cell activity of porcine c-kit+ hematopoietic cells. Exp Hematol 31:833-40
Giovino, Maria A; Down, Julian D; Jackson, John D et al. (2002) Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies. Transplantation 73:723-31
Heinz, Matthew; Huang, Christene A; Emery, David W et al. (2002) Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol 30:809-15
Sykes, M; Sachs, D H (2001) Mixed chimerism. Philos Trans R Soc Lond B Biol Sci 356:707-26
Wekerle, T; Sykes, M (2001) Mixed chimerism and transplantation tolerance. Annu Rev Med 52:353-70
Chen, A M; Zhou, Y; Swenson, K et al. (2000) Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. Transplantation 69:2484-90
Abe, M; Chen, A M; Qi, J et al. (2000) Porcine stem cell factor facilitates long-lasting porcine hematopoietic engraftment in murine recipients. Transplant Proc 32:1047

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