Potassium Channel Modulation by G-Protein Subunits

Logothetis, Diomedes E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL054185-01A1
• Application #: 2232470
• Study Section: Cardiovascular and Pulmonary Research A Study Section (CVA)
• Project Start: 1996-03-08
• Project End: 2001-01-31
• Budget Start: 1996-03-08
• Budget End: 1997-01-31
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Mount Sinai School of Medicine
• Department: Physiology
• Type: Schools of Medicine
• City: New York
• State: NY
• Country: United States
• Zip Code: 10029

Publications

Rusinova, Radda; Shen, Yu-Ming Albert; Dolios, Georgia et al. (2009) Mass spectrometric analysis reveals a functionally important PKA phosphorylation site in a Kir3 channel subunit. Pflugers Arch 458:303-14

Rosenhouse-Dantsker, Avia; Logothetis, Diomedes E (2007) Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix. Channels (Austin) 1:189-97

Rusinova, Radda; Mirshahi, Tooraj; Logothetis, Diomedes E (2007) Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits. J Biol Chem 282:34019-30

Mirshahi, Tooraj; Logothetis, Diomedes E; Rosenhouse-Dantsker, Avia (2006) Hydrogen-bonding dynamics between adjacent blades in G-protein beta-subunit regulates GIRK channel activation. Biophys J 90:2776-85

Rosenhouse-Dantsker, Avia; Logothetis, Diomedes E (2006) New roles for a key glycine and its neighboring residue in potassium channel gating. Biophys J 91:2860-73

Mirshahi, Tooraj; Logothetis, Diomedes E (2004) Molecular determinants responsible for differential cellular distribution of G protein-gated inwardly rectifying K+ channels. J Biol Chem 279:11890-7

Peng, Luying; Mirshahi, Tooraj; Zhang, Hailin et al. (2003) Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity. J Biol Chem 278:50203-11

He, Cheng; Yan, Xixin; Zhang, Hailin et al. (2002) Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. J Biol Chem 277:6088-96

Rohacs, Tibor; Lopes, Coeli; Mirshahi, Tooraj et al. (2002) Assaying phosphatidylinositol bisphosphate regulation of potassium channels. Methods Enzymol 345:71-92

Mirshahi, Tooraj; Mittal, Vivek; Zhang, Hailin et al. (2002) Distinct sites on G protein beta gamma subunits regulate different effector functions. J Biol Chem 277:36345-50