Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL054912-01A1
Application #
2233422
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-05-01
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Genetics
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Jagatheesan, Ganapathy; Rajan, Sudarsan; Wieczorek, David F (2010) Investigations into tropomyosin function using mouse models. J Mol Cell Cardiol 48:893-8
Prabhakar, Rethinasamy; Petrashevskaya, Natalia; Schwartz, Arnold et al. (2003) A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Mol Cell Biochem 251:33-42
Pieples, Kathy; Arteaga, Grace; Solaro, R John et al. (2002) Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation. Am J Physiol Heart Circ Physiol 283:H1344-53
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Prabhakar, R; Boivin, G P; Grupp, I L et al. (2001) A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. J Mol Cell Cardiol 33:1815-28
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Prabhakar, R; Boivin, G P; Hoit, B et al. (1999) Rescue of high expression beta-tropomyosin transgenic mice by 5-propyl-2-thiouracil. Regulating the alpha-myosin heavy chain promoter. J Biol Chem 274:29558-63
Muthuchamy, M; Pieples, K; Rethinasamy, P et al. (1999) Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction. Circ Res 85:47-56
Rethinasamy, P; Muthuchamy, M; Hewett, T et al. (1998) Molecular and physiological effects of alpha-tropomyosin ablation in the mouse. Circ Res 82:116-23

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