Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055273-01
Application #
2233828
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-07-15
Project End
2000-05-31
Budget Start
1996-07-15
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
American National Red Cross
Department
Type
DUNS #
003255213
City
Washington
State
DC
Country
United States
Zip Code
20006
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Klinge, J; Auerswald, G; Budde, U et al. (2001) Detection of all anti-factor VIII antibodies in haemophilia A patients by the Bethesda assay and a more sensitive immunoprecipitation assay. Haemophilia 7:26-32
Barrow, R T; Healey, J F; Gailani, D et al. (2000) Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules. Blood 95:564-8
Fay, P J; Scandella, D (1999) Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa. J Biol Chem 274:29826-30
Laub, R; Di Giambattista, M; Fondu, P et al. (1999) Inhibitors in German hemophilia A patients treated with a double virus inactivated factor VIII concentrate bind to the C2 domain of FVIII light chain. Thromb Haemost 81:39-44
Sawamoto, Y; Prescott, R; Zhong, D et al. (1998) Dominant C2 domain epitope specificity of inhibitor antibodies elicited by a heat pasteurized product, factor VIII CPS-P, in previously treated hemophilia A patients without inhibitors. Thromb Haemost 79:62-8
Saenko, E L; Scandella, D; Yakhyaev, A V et al. (1998) Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets. J Biol Chem 273:27918-26
Saenko, E L; Scandella, D (1997) The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor. J Biol Chem 272:18007-14
Thompson, A R; Murphy, M E; Liu, M et al. (1997) Loss of tolerance to exogenous and endogenous factor VIII in a mild hemophilia A patient with an Arg593 to Cys mutation. Blood 90:1902-10