Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055404-01
Application #
2233980
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-03-08
Project End
2001-01-31
Budget Start
1996-03-08
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Physiology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kuryshev, Yuri A; Ficker, Eckhard; Wang, Lu et al. (2005) Pentamidine-induced long QT syndrome and block of hERG trafficking. J Pharmacol Exp Ther 312:316-23
Ficker, Eckhard; Kuryshev, Yuri A; Dennis, Adrienne T et al. (2004) Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol Pharmacol 66:33-44
Laurita, Kenneth R; Chuck, Emil Thomas; Yang, Tianen et al. (2003) Optical mapping reveals conduction slowing and impulse block in iron-overload cardiomyopathy. J Lab Clin Med 142:83-9
Ficker, Eckhard; Dennis, Adrienne T; Wang, Lu et al. (2003) Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res 92:e87-100
Obejero-Paz, Carlos A; Yang, Tianen; Dong, Wei-Qiang et al. (2003) Deferoxamine promotes survival and prevents electrocardiographic abnormalities in the gerbil model of iron-overload cardiomyopathy. J Lab Clin Med 141:121-30
Schwalbe, Ruth A; Rudin, Alicia; Xia, Shen-Ling et al. (2002) Site-directed glycosylation tagging of functional Kir2.1 reveals that the putative pore-forming segment is extracellular. J Biol Chem 277:24382-9
Wible, Barbara A; Wang, Liming; Kuryshev, Yuri A et al. (2002) Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells. J Biol Chem 277:17852-62
Peri, R; Wible, B A; Brown, A M (2001) Mutations in the Kv beta 2 binding site for NADPH and their effects on Kv1.4. J Biol Chem 276:738-41
Kuryshev, Y A; Wible, B A; Gudz, T I et al. (2001) KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. Am J Physiol Cell Physiol 281:C290-9
Thomas, D; Wendt-Nordahl, G; Rockl, K et al. (2001) High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872. J Pharmacol Exp Ther 297:753-61

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