Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL056593-06
Application #
6691061
Study Section
Metabolism Study Section (MET)
Program Officer
Wassef, Momtaz K
Project Start
1998-05-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
6
Fiscal Year
2004
Total Cost
$291,000
Indirect Cost
Name
University of Wisconsin Madison
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Blasiole, Daniel A; Oler, Angie T; Attie, Alan D (2008) Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283:11374-81
Flowers, Jessica B; Rabaglia, Mary E; Schueler, Kathryn L et al. (2007) Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56:1228-39
Attie, Alan D; Flowers, Matthew T; Flowers, Jessica B et al. (2007) Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes. Nutr Rev 65:S35-8
Nassoury, Nasha; Blasiole, Daniel A; Tebon Oler, Angie et al. (2007) The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR. Traffic 8:718-32
Yi, Nengjun; Shriner, Daniel; Banerjee, Samprit et al. (2007) An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects. Genetics 176:1865-77
Attie, Alan D; Flowers, Matthew T; Flowers, Jessica B et al. (2007) Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes. Novartis Found Symp 286:47-53;discussion 54-7, 162-3, 1
Blasiole, Daniel A; Davis, Roger A; Attie, Alan D (2007) The physiological and molecular regulation of lipoprotein assembly and secretion. Mol Biosyst 3:608-19
Flowers, Matthew T; Groen, Albert K; Oler, Angie Tebon et al. (2006) Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet. J Lipid Res 47:2668-80
Lan, Hong; Chen, Meng; Flowers, Jessica B et al. (2006) Combined expression trait correlations and expression quantitative trait locus mapping. PLoS Genet 2:e6
Benjannet, Suzanne; Rhainds, David; Essalmani, Rachid et al. (2004) NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 279:48865-75

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