Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL056686-01
Application #
2235165
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1996-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical University of South Carolina
Department
Biochemistry
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Yu, Hongrun; Song, Qing; Freedman, Barry I et al. (2002) Association of the tissue kallikrein gene promoter with ESRD and hypertension. Kidney Int 61:1030-9
Dobrzynski, E; Yoshida, H; Chao, J et al. (1999) Adenovirus-mediated kallikrein gene delivery attenuates hypertension and protects against renal injury in deoxycorticosterone-salt rats. Immunopharmacology 44:57-65
Zhang, J J; Wang, C; Lin, K F et al. (1999) Human tissue kallikrein attenuates hypertension and secretes into circulation and urine after intramuscular gene delivery in hypertensive rats. Clin Exp Hypertens 21:1145-60
Murakami, H; Yayama, K; Chao, J et al. (1999) Atrial natriuretic peptide gene delivery attenuates gentamycin-induced nephrotoxicity in rats. Nephrol Dial Transplant 14:1376-84
Zhang, J J; Chao, L; Chao, J (1999) Adenovirus-mediated kallikrein gene delivery reduces aortic thickening and stroke-induced death rate in Dahl salt-sensitive rats. Stroke 30:1925-31;discussion 1931-2
Lin, K F; Chao, J; Chao, L (1999) Atrial natriuretic peptide gene delivery reduces stroke-induced mortality rate in Dahl salt-sensitive rats. Hypertension 33:219-24
Chao, J; Zhang, J J; Lin, K F et al. (1998) Adenovirus-mediated kallikrein gene delivery reverses salt-induced renal injury in Dahl salt-sensitive rats. Kidney Int 54:1250-60
Wang, C; Chao, C; Madeddu, P et al. (1998) Central delivery of human tissue kallikrein gene reduces blood pressure in hypertensive rats. Biochem Biophys Res Commun 244:449-54
Lin, K F; Chao, J; Chao, L (1998) Atrial natriuretic peptide gene delivery attenuates hypertension, cardiac hypertrophy, and renal injury in salt-sensitive rats. Hum Gene Ther 9:1429-38
Yayama, K; Wang, C; Chao, L et al. (1998) Kallikrein gene delivery attenuates hypertension and cardiac hypertrophy and enhances renal function in Goldblatt hypertensive rats. Hypertension 31:1104-10

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