Mechanisms of Oxidant Mediated Endothelial Dysfunction

Natarajan, Viswanathan

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL057260-01A1
• Application #: 2487350
• Study Section: Special Emphasis Panel (ZRG4-ALTX-4 (01))
• Project Start: 1998-01-01
• Project End: 1998-06-30
• Budget Start: 1998-01-01
• Budget End: 1998-06-30
• Support Year: 1
• Fiscal Year: 1998

Institution

• Name: Indiana University-Purdue University at Indianapolis
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 005436803
• City: Indianapolis
• State: IN
• Country: United States
• Zip Code: 46202

Publications

Ford, Lincoln E; Gilbert, Susan H (2007) Mechanism and significance of early, rapid shortening in sensitized airway smooth muscle. Can J Physiol Pharmacol 85:747-53

Usatyuk, Peter V; Vepa, Suryanarayana; Watkins, Tonya et al. (2003) Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells. Antioxid Redox Signal 5:723-30

Usatyuk, Peter V; Fomin, Victor P; Shi, Shu et al. (2003) Role of Ca2+ in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol 285:L1006-17

Roy, Shukla; Parinandi, Narasimham; Zeigelstein, Roy et al. (2003) Hyperoxia alters phorbol ester-induced phospholipase D activation in bovine lung microvascular endothelial cells. Antioxid Redox Signal 5:217-28

Cummings, Rhett; Parinandi, Narasimham; Wang, Lixin et al. (2002) Phospholipase D/phosphatidic acid signal transduction: role and physiological significance in lung. Mol Cell Biochem 234-235:99-109

Hu, Qinghua; Natarajan, Viswanathan; Ziegelstein, Roy C (2002) Phospholipase D regulates calcium oscillation frequency and nuclear factor-kappaB activity in histamine- stimulated human endothelial cells. Biochem Biophys Res Commun 292:325-32

Gupta, M P; Ober, M D; Patterson, C et al. (2001) Nitric oxide attenuates H(2)O(2)-induced endothelial barrier dysfunction: mechanisms of protection. Am J Physiol Lung Cell Mol Physiol 280:L116-26

Natarajan, V; Scribner, W M; Morris, A J et al. (2001) Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells. Am J Physiol Lung Cell Mol Physiol 281:L435-49

Shi, S; Garcia, J G; Roy, S et al. (2000) Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 279:L441-51

Parinandi, N L; Scribner, W M; Vepa, S et al. (1999) Phospholipase D activation in endothelial cells is redox sensitive. Antioxid Redox Signal 1:193-210