Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL058688-03
Application #
6184287
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1998-09-01
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$327,143
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Soares, Miguel P; Bach, Fritz H (2009) Heme oxygenase-1: from biology to therapeutic potential. Trends Mol Med 15:50-8
Ollinger, Robert; Wang, Hongjun; Yamashita, Kenichiro et al. (2007) Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal 9:2175-85
Soares, Miguel P; Bach, Fritz H (2007) Heme oxygenase-1 in organ transplantation. Front Biosci 12:4932-45
Yamashita, Kenichiro; Ollinger, Robert; McDaid, James et al. (2006) Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. FASEB J 20:776-8
Bilban, Martin; Bach, Fritz H; Otterbein, Sherrie L et al. (2006) Carbon monoxide orchestrates a protective response through PPARgamma. Immunity 24:601-10
McDaid, James; Yamashita, Kenichiro; Chora, Angelo et al. (2005) Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J 19:458-60
Berberat, Pascal O; A-Rahim, Yousif I; Yamashita, Kenichiro et al. (2005) Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis. Inflamm Bowel Dis 11:350-9
Soares, Miguel P; Seldon, Mark P; Gregoire, Isabel Pombo et al. (2004) Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. J Immunol 172:3553-63
Nakao, Atsunori; Otterbein, Leo E; Overhaus, Marcus et al. (2004) Biliverdin protects the functional integrity of a transplanted syngeneic small bowel. Gastroenterology 127:595-606
Otterbein, Leo E; Soares, Miguel P; Yamashita, Kenichiro et al. (2003) Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol 24:449-55

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