Abstract

Modern helical CT technology, coupled with a rapid tntravenous infusion of iodinated contrast media, allows for the creation of volumetric angiograms. To date, volumetric angiograms have been visualized qualitatively with various three-dimensional rendering techniques, but a systematic, quantitative analysis of blood vessel morphology has not been conducted. Our goal is to develop and validate a method of volumetric analysis that enables quantification of cross-sectional areas of blood vessels, path lengths, curvature and branch angulation, as well as mural plaque/thrombus characteristics such as volume, calcification and irregularity. We will validate these measurements in idealized and anthropomorphic phantoms, and then apply the volumetric analysis to the problem of characterizing the aorta and its branches for the purpose of endovascular repair of aortic aneurysms with stent-grafts. In the clinical application phase of our work, we will test the hypothesis that volumetric analysis of helical CT angiograms improves planning for endovascular prosthesis deployment, leads to a lower proportion of adverse outcomes, and may obviate the need for invasive arteriography from pre-deployment evaluation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL058915-04
Application #
6476787
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Baldwin, Tim
Project Start
1999-01-01
Project End
2005-11-30
Budget Start
2001-12-01
Budget End
2005-11-30
Support Year
4
Fiscal Year
2002
Total Cost
$349,179
Indirect Cost

  Institution

Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Rubin, Geoffrey D; Leipsic, Jonathon; Joseph Schoepf, U et al. (2014) CT angiography after 20 years: a transformation in cardiovascular disease characterization continues to advance. Radiology 271:633-52
Ueda, Takuya; Fleischmann, Dominik; Dake, Michael D et al. (2010) Incomplete endograft apposition to the aortic arch: bird-beak configuration increases risk of endoleak formation after thoracic endovascular aortic repair. Radiology 255:645-52
Raman, Bhargav; Raman, Raghav; Napel, Sandy et al. (2010) Automated quantification of aortoaortic and aortoiliac angulation for computed tomographic angiography of abdominal aortic aneurysms before endovascular repair: preliminary study. J Vasc Interv Radiol 21:1746-50
Won, Joong-Ho; Rosenberg, Jarrett; Rubin, Geoffrey D et al. (2009) Uncluttered single-image visualization of the abdominal aortic vessel tree: method and evaluation. Med Phys 36:5245-60
Zhao, Shao-hong; Logan, Laura; Schraedley, Pamela et al. (2009) Assessment of the anterior spinal artery and the artery of Adamkiewicz using multi-detector CT angiography. Chin Med J (Engl) 122:145-9
Raman, Raghav; Raman, Bhargav; Napel, Sandy et al. (2008) Semiautomated quantification of the mass and distribution of vascular calcification with multidetector CT: method and evaluation. Radiology 247:241-50
Raman, Raghav; Raman, Bhargav; Napel, Sandy et al. (2008) Improved speed of bone removal in computed tomographic angiography using automated targeted morphological separation: method and evaluation in computed tomographic angiography of lower extremity occlusive disease. J Comput Assist Tomogr 32:485-91
Peng, Peter D; Spain, David A; Tataria, Monika et al. (2008) CT angiography effectively evaluates extremity vascular trauma. Am Surg 74:103-7
Ueda, Takuya; Fleischmann, Dominik; Rubin, Geoffrey D et al. (2008) Imaging of the thoracic aorta before and after stent-graft repair of aneurysms and dissections. Semin Thorac Cardiovasc Surg 20:348-357
Hsu, Charles S; Hellinger, Jeffrey C; Rubin, Geoffrey D et al. (2008) CT angiography in pediatric extremity trauma: preoperative evaluation prior to reconstructive surgery. Hand (N Y) 3:139-45

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