Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL061558-07
Application #
6725298
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Program Officer
Buxton, Denis B
Project Start
1999-01-11
Project End
2004-08-31
Budget Start
2004-01-01
Budget End
2004-08-31
Support Year
7
Fiscal Year
2004
Total Cost
$214,628
Indirect Cost
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Yoo, ByungSu; Lemaire, Anthony; Mangmool, Supachoke et al. (2009) Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol 297:H1377-86
Volovyk, Zoya M; Wolf, Matthew J; Prasad, Sathyamangla V Naga et al. (2006) Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover. J Biol Chem 281:9773-80
Perrino, Cinzia; Naga Prasad, Sathyamangla V; Patel, Mrinali et al. (2005) Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. J Am Coll Cardiol 45:1862-70
Perrino, Cinzia; Naga Prasad, Sathyamangla V; Schroder, Jacob N et al. (2005) Restoration of beta-adrenergic receptor signaling and contractile function in heart failure by disruption of the betaARK1/phosphoinositide 3-kinase complex. Circulation 111:2579-87
Seubert, John; Yang, Baichun; Bradbury, J Alyce et al. (2004) Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res 95:506-14
Colomer, Josep M; Mao, Lan; Rockman, Howard A et al. (2003) Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo. Mol Endocrinol 17:183-92
Esposito, Giovanni; Rapacciuolo, Antonio; Naga Prasad, Sathyamangla V et al. (2002) Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation 105:85-92
Naga Prasad, Sathyamangla V; Laporte, Stephane A; Chamberlain, Dean et al. (2002) Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J Cell Biol 158:563-75
Rapacciuolo, A; Esposito, G; Caron, K et al. (2001) Important role of endogenous norepinephrine and epinephrine in the development of in vivo pressure-overload cardiac hypertrophy. J Am Coll Cardiol 38:876-82
Harding, V B; Jones, L R; Lefkowitz, R J et al. (2001) Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Proc Natl Acad Sci U S A 98:5809-14

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