The Stanford collaborative R01 proposal is a response to the NHLBI RFA, """"""""Molecular and Physical Characterization of the Vulnerable Plaque,"""""""" and is submitted by a highly-integrated multi-disciplinary group which will use innovative vascular biology and imaging to gain new insights into the determinants of plaque vulnerability, and which plans to develop effective imaging technology to detect vulnerable plaque. In this project, """"""""Magnetic Resonance Imaging of the Vulnerable Plaque,"""""""" we intend to develop new imaging methodologies that will provide ultra- high resolution images of the arterial plaque in vivo. These include motion-compensated 2D and 3D data acquisition using the diminishing variance algorithm as well as a new high-resolution intravascular imaging system that operates in real-time. We have a history of collaboration; institutional resources, cutting- edge technology in vascular biology and imaging; and investigators with established track records in fundamental research and technology transfer in IVUS, MR imaging, vascular biology, and vascular medicine. This proposal, will likely yield new insights into the mechanisms of plaque rupture, and new modalities for detecting vulnerable plaque.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL061864-03
Application #
6184548
Study Section
Special Emphasis Panel (ZHL1-CSR-B (S1))
Project Start
1998-09-30
Project End
2002-08-31
Budget Start
2000-09-30
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$314,578
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Cunningham, Charles H; Arai, Takayasu; Yang, Phillip C et al. (2005) Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med 53:999-1005
Rivas, Pedro A; Nayak, Krishna S; Scott, Greig C et al. (2002) In vivo real-time intravascular MRI. J Cardiovasc Magn Reson 4:223-32