Elevated concentrations of plasma low density lipoprotein cholesterol (LDL-C), a major risk factor for coronary heart disease, cluster significantly in families. This clustering has been observed in cross-sectional studies in both black and white families, but longitudinal data on the familial clustering of LDL-C are virtually nonexistent. The proposed study will provide new and important information about changes in the familial LDL-C correlations in black and white families from the period of shared household environments to that of separate households, using families from the Princeton Lipid Research Clinics (LRC) Prevalence (1973-75) and Family Studies (1975-76). The proposed study will also provide important information on changes in individual LDL-C levels over the same 25 year period. The former student participants were six to 18 years of age and are now 32 to 45 years of age; their parents were (largely) 26 to 55 years of age and are now 51 to 80 years of age. Plasma LDL-C concentrations in children and adults have been shown to associate with the apolipoprotein (apo) E genotype, with obesity, and with such elective behaviors as diet, cigarette smoking, and physical activity. In the LRC Study, measurements were made of LDL-C, body habitus, elective behaviors, and the family history of cardiovascular disease (CVD). The proposed study will obtain repeat measures of these factors, plus determine the apo E isoforms. Changes in individual LDL-C levels and in familial associations can then be assessed in association with apo E isoforms, body composition, elective behaviors, and family history of CVD. Family members share ranges of body weight, patterns of fat distribution, dietary and smoking habits, and physical activity levels. The extent to which the familial clustering of LDL-C levels is determined by apo E isoforms interacting with the similar levels of obesity, and with the similar behaviors, is not currently known. The investigators state that data from this study will provide new insights into mechanisms for the clustering of LDL-C levels. They further state that the factors influencing long term changes in LDL-C levels will be clarified and an understanding of environmental and genetic influences gained. They conclude that this information can be used to improve prediction of future CHD risk and to formulate interventions.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL062394-01A1
Application #
6052056
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
2000-07-01
Project End
2004-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$510,952
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Woo, Jessica G; Morrison, John A; Stroop, Davis M et al. (2014) Genetic architecture of lipid traits changes over time and differs by race: Princeton Lipid Follow-up Study. J Lipid Res 55:1515-24
Glueck, Charles J; Morrison, John A; Wang, Ping et al. (2013) Early and late menarche are associated with oligomenorrhea and predict metabolic syndrome 26 years later. Metabolism 62:1597-606
Oikonen, Mervi; Laitinen, Tomi T; Magnussen, Costan G et al. (2013) Ideal cardiovascular health in young adult populations from the United States, Finland, and Australia and its association with cIMT: the International Childhood Cardiovascular Cohort Consortium. J Am Heart Assoc 2:e000244
Laitinen, Tomi T; Pahkala, Katja; Venn, Alison et al. (2013) Childhood lifestyle and clinical determinants of adult ideal cardiovascular health: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Princeton Follow-Up Study. Int J Cardiol 169:126-32
Dwyer, Terence; Sun, Cong; Magnussen, Costan G et al. (2013) Cohort Profile: the international childhood cardiovascular cohort (i3C) consortium. Int J Epidemiol 42:86-96
Morrison, John A; Glueck, Charles J; Wang, Ping (2012) The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up Study. J Pediatr 160:590-597.e3
Morrison, John A; Glueck, Charles J; Wang, Ping (2012) Childhood risk factors predict cardiovascular disease, impaired fasting glucose plus type 2 diabetes mellitus, and high blood pressure 26 years later at a mean age of 38 years: the Princeton-lipid research clinics follow-up study. Metabolism 61:531-41
Shi, L; Morrison, J A; Wiecha, J et al. (2011) Healthy lifestyle factors associated with reduced cardiometabolic risk. Br J Nutr 105:747-54
Glueck, Charles J; Morrison, John A (2011) Pediatric non-high-density lipoprotein cholesterol, the metabolic syndrome, and insulin resistance. J Pediatr 158:179-81
Morrison, John A; Glueck, Charles J; Wang, Ping (2010) Preteen insulin levels interact with caloric intake to predict increases in obesity at ages 18 to 19 years: a 10-year prospective study of black and white girls. Metabolism 59:718-27

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