The goal of the work proposed in this application is to investigate coronary artery calcium (CAC), detected by electron beam computed tomography (EBCT), as a predictor of coronary heart disease (CHD) mortality and morbidity, stroke, and all-cause mortality in a historical cohort epidemiological study. The study population includes 5,400 and 12,600 men who had or will have had at least one evaluation of the presence of CAC by EBCT examination at a preventive medicine clinical during the interval 1995 to 1999. Follow-up of these individuals will be for an average of about 2.75 years with approximately 15,000 woman-years and 35,000 man-years of observations being available for analyses by June 30, 2000. We expect 248 deaths including 94 from CHD, 364 non-fatal myocardial infarctions (MI), and 84 non-fatal strokes. An important strength of the proposed study is the self-reported key health variables at baseline for all study participants. In addition, objective measures of blood pressure, total cholesterol, HDL- cholesterol, triglyceride, plasma glucose, resting and exercise electrocardiograms (ECG), maximal health rates, cardiorespiratory fitness, and other clinical and biochemical measurements are available for about half of the participants. CAC by EBCT has been associated with prevalent CHD and with incident CHD in recent small prospective studies. However, it is unclear whether CAC is predictive of MI or CHD deaths, because currently available studies had few individuals with evidence of hard CVD endpoints. In this proposed study, the large cohort morbidity, stroke, and all- cause mortality in terms of thresholds or dose-response effects. An additional strength of this proposed study is that exercise test results and measures of conventional CHD risk factors, including several health behaviors and biochemical markers, are available for about 50% of the participants. This will allow us to evaluate the separate and independent predictive value of CAC and exercise test results and the combination of these two exposures in relation to study outcomes. Furthermore, we will use CAC scores, exercise test results, and the presence of conventional risk factors together to identify participants at the highest risk of developing CHD outcomes. This study has the potential to make important contributions to the assess of subclinical CHD, and may have implications for prevention of CHD.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL062508-01
Application #
2836838
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1999-09-30
Project End
2002-08-31
Budget Start
1999-09-30
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Cooper Institute
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75230
Meier, Nathan F; Lee, Duck-Chul; Sui, Xuemei et al. (2018) Physical Activity, Cardiorespiratory Fitness, and Incident Glaucoma. Med Sci Sports Exerc 50:2253-2258
Bakker, Esmée A; Lee, Duck-Chul; Sui, Xuemei et al. (2018) Association of Resistance Exercise With the Incidence of Hypercholesterolemia in Men. Mayo Clin Proc 93:419-428
Bakker, Esmée A; Lee, Duck-Chul; Sui, Xuemei et al. (2017) Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome. Mayo Clin Proc 92:1214-1222
Sui, Xuemei; Ott Jr, John; Becofsky, Katie et al. (2017) Cardiorespiratory Fitness and All-Cause Mortality in Men With Emotional Distress. Mayo Clin Proc 92:918-924
Sui, Xuemei; Sarzynski, Mark A; Lee, Duck-Chul et al. (2017) Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women. Am J Med 130:469-476.e2
Breneman, Charity B; Polinski, Kristen; Sarzynski, Mark A et al. (2016) The Impact of Cardiorespiratory Fitness Levels on the Risk of Developing Atherogenic Dyslipidemia. Am J Med 129:1060-6
Lee, Duck-chul; Lavie, Carl J; Sui, Xuemei et al. (2016) Running and Mortality: Is More Actually Worse? Mayo Clin Proc 91:534-6
Jiménez-Pavón, David; Artero, Enrique G; Lee, Duck-Chul et al. (2016) Cardiorespiratory Fitness and Risk of Sudden Cardiac Death in Men and Women in the United States: A Prospective Evaluation From the Aerobics Center Longitudinal Study. Mayo Clin Proc 91:849-57
Ortega, Francisco B; Sui, Xuemei; Lavie, Carl J et al. (2016) Body Mass Index, the Most Widely Used But Also Widely Criticized Index: Would a Criterion Standard Measure of Total Body Fat Be a Better Predictor of Cardiovascular Disease Mortality? Mayo Clin Proc 91:443-55
Greer, Anna E; Sui, Xuemei; Maslow, Andréa L et al. (2015) The effects of sedentary behavior on metabolic syndrome independent of physical activity and cardiorespiratory fitness. J Phys Act Health 12:68-73

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