A relation of lowered cholesterol to increased aggressive behaviors (including suicide) and impaired cognition has been variably demonstrated and remains to be established or excluded with confidence. HMG-CoA reductase inhibitors (""""""""statins"""""""") are the most widely used agents and their effects are of special interest. Purpose: To examine the effect of statins on aggressive responding, cognition, and serotonin in individuals with moderate LDL and no identified cardiovascular disease (CVD). Hypothesis: Statin therapy will increase aggressive responding on the PSAP (Point Subtraction Aggression paradigm, a standardized aggression measure that correlates with both violent behavior and serotonin); will reduce measures of cognition (including psychomotor speed and attention); and will change serotonin (gauged by whole blood serotonin), which may be a mediator of effects on behavior and perhaps cognition. Secondarily, it is hypothesized that simvastatin (lipophilic) will exert more potent effects on cognition (and perhaps aggression) than pravastatin (hydrophilic); that serotonin (5HT) changes will related to changes in aggressive responding and perhaps cognition; and that a """"""""susceptible subset"""""""" may be defined by baseline characteristics including biochemistry, mood, personality, and extremes of cardiovascular reactivity.
| Golomb, Beatrice A; Dimsdale, Joel E; Koslik, Hayley J et al. (2015) Statin Effects on Aggression: Results from the UCSD Statin Study, a Randomized Control Trial. PLoS One 10:e0124451 |
| Golomb, Beatrice Alexandra; Bui, Alexis K (2015) A Fat to Forget: Trans Fat Consumption and Memory. PLoS One 10:e0128129 |
| Golomb, Beatrice A; Evans, Marcella A; White, Halbert L et al. (2012) Trans fat consumption and aggression. PLoS One 7:e32175 |
| Golomb, Beatrice A; Chan, Virginia T; Evans, Marcella A et al. (2012) The older the better: are elderly study participants more non-representative? A cross-sectional analysis of clinical trial and observational study samples. BMJ Open 2: |
| Golomb, Beatrice A; Evans, Marcella A; Dimsdale, Joel E et al. (2012) Effects of statins on energy and fatigue with exertion: results from a randomized controlled trial. Arch Intern Med 172:1180-2 |
| Golomb, Beatrice A; Koperski, Sabrina; White, Halbert L (2012) Association between more frequent chocolate consumption and lower body mass index. Arch Intern Med 172:519-21 |
| Rose, Natalie; Koperski, Sabrina; Golomb, Beatrice A (2010) Mood food: chocolate and depressive symptoms in a cross-sectional analysis. Arch Intern Med 170:699-703 |
| Golomb, Beatrice A; Yaghmai, Reza; Renvall, Marian J et al. (2010) Electronic medical records and upper extremity symptoms: pain with the gain? Arch Intern Med 170:655-7 |
| Cham, Stephanie; Evans, Marcella A; Denenberg, Julie O et al. (2010) Statin-associated muscle-related adverse effects: a case series of 354 patients. Pharmacotherapy 30:541-53 |
| Golomb, Beatrice A; Evans, Marcella A (2008) Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism. Am J Cardiovasc Drugs 8:373-418 |
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