Stereotaxic neurosurgical techniques and baroreflex challenges will be employed in the chronically-instrumented fetal sheep to surgically disconnect the PVN to evaluate the extent to which and the mechanisms by which the late gestation fetal sheep PVN: (1) modifies normal development of brainstem and sympathetic preganglionic neuron regulation of peripheral vascular tone; and (2) is a site for production of glucocorticoid-induced hypertension.
| Gilbert, Jeffrey S; Ford, Stephen P; Lang, A Lee et al. (2007) Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus. Pediatr Res 61:42-7 |
| Gilbert, Jeffrey S; Cox, Laura A; Mitchell, Graham et al. (2006) Nutrient-restricted fetus and the cardio-renal connection in hypertensive offspring. Expert Rev Cardiovasc Ther 4:227-37 |
| Gilbert, Jeffrey S; Lang, Alvin L; Grant, Angela R et al. (2005) Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age. J Physiol 565:137-47 |
| Gilbert, Jeffrey S; Lang, Alvin L; Nijland, Mark J (2005) Maternal nutrient restriction and the fetal left ventricle: decreased angiotensin receptor expression. Reprod Biol Endocrinol 3:27 |
| McDonald, T J; Franko, K L; Brown, J M et al. (2003) Betamethasone in the last week of pregnancy causes fetal growth retardation but not adult hypertension in rats. J Soc Gynecol Investig 10:469-73 |
