Abstract

The objective of this proposal is to generate data that can be useful in determining how system perturbations, such as hypoxia, gasping, and vagal and peripheral chemoreceptor activities, result in changes in respiratory patterns during maturation. The phrenic neurogram will be assessed as it exhibits features that reflect the dynamics of the phrenic respiratory pattern generator. The investigators will employ a technique known as non-linear neural dynamical analysis as a useful measure of quantifying the complexity of both physical systems and physiological signals. This will be applied to piglets at advancing postnatal ages during eupnea, before and after vagotomy, hypercapnia and hypoxic gasping, in the presence and absence of chemodenervation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL065732-01
Application #
6194117
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
2000-09-01
Project End
2004-06-30
Budget Start
2000-09-01
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$318,986
Indirect Cost

  Institution

Name
Dartmouth College
Department
Type
Schools of Engineering
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Akkurt, David; Akay, Yasemin M; Akay, Metin (2009) The effects of elevated body temperature on the complexity of the diaphragm EMG signals during maturation. J Neural Eng 6:024001
Dragomir, Andrei; Akay, Yasemin; Curran, Aidan K et al. (2008) Investigating the complexity of respiratory patterns during the laryngeal chemoreflex. J Neuroeng Rehabil 5:17
Dragomir, Andrei; Akay, Yasemin; Curran, Aidan K et al. (2008) Complexity measures of the central respiratory networks during wakefulness and sleep. J Neural Eng 5:254-61
Akay, Metin; Ichinoseki-Sekine, Noriko (2006) The effects of hypercapnia on early and later phases of phrenic neurogram during early maturation. IEEE Trans Biomed Eng 53:1250-4
Akay, Metin (2005) CO2 sensitivity of the complexity of phrenic neurograms in the piglet during early maturation. J Neural Eng 2:35-41
Akay, Metin (2005) Influence of the vagus nerve on respiratory patterns during early maturation. IEEE Trans Biomed Eng 52:1863-8
Akay, M (2005) Influence of peripheral chemodenervation on the complexity of respiratory patterns during early maturation. Med Biol Eng Comput 43:793-9
Akay, M; Sekine, M; Moodie, K L (2004) Nonlinear dynamics of respiratory patterns during maturation. Methods Inf Med 43:99-101
Akay, Metin; Sekine, Noriko (2004) Investigating the complexity of respiratory patterns during recovery from severe hypoxia. J Neural Eng 1:16-20
Akay, Metin; Sekine, Masaki (2004) The effects of maturation on early and late phases of phrenic neurogram during eupnea. IEEE Trans Biomed Eng 51:1954-9

Showing the most recent 10 out of 14 publications