Heart failure is one of the most important causes of morbidity and mortality in the United States and strategies to reduce its burden to society require a greater understanding of human myocardial dysfunction and its natural history. The most common etiology of heart failure in the U.S. is coronary artery disease and thus the earliest manifestations of systolic myocardial dysfunction in humans are likely to be regional in nature. However, a large proportion of patients with heart failure have diastolic dysfunction with preserved systolic function. In these, hypertension and aging are established pre-disposing factors but early precursors of this condition remain unknown. Previous longitudinal studies aimed at elucidating the pathophysiology of heart failure were not structured to measure regional alterations of systolic and/or diastolic function directly. This study was specifically designed to fill this knowledge gap by obtaining MRI tagging studies in 2,126 participants of the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline for the purpose of detecting the earliest manifestations of systolic and diastolic myocardial dysfunction in humans. In this continuation study, we propose to repeat MRI tagging in 1,300 of those participants to define the natural history of changes in regional and global systolic and diastolic function relative to the development and progression of sub-clinical disease and risk factors over 3-5 years. In addition, we will also examine whether changes in regional function predict the development of global LV dysfunction, symptomatic congestive heart failure and death. Baseline cross-sectional analyses will be used to define markers and risk factors of interest. Pilot studies on the magnitude of regional function change from 60 particpants over 1-2 years indicate that the proposed studies have ample power to test all specific aims. The same MRI protocol and analytical tools will be used to assure precise comparisons with baseline data. We expect to define the natural history of myocardial dysfunction in humans of different ethnicities and different exposures to risk factors. We anticipate that these studies will permit the identification of the earliest precursors of heart failure by demonstrating crucial relationships between sub-clinical disease and incident regional myocardial dysfunction, and between regional dysfunction and incident symptomatic failure. These findings will be pivotal to the design of future strategies to forestall progressive myocardial dysfunction and prevent the development of heart failure.
| Ohyama, Yoshiaki; Redheuil, Alban; Kachenoura, Nadjia et al. (2018) Imaging Insights on the Aorta in Aging. Circ Cardiovasc Imaging 11:e005617 |
| Moazzami, Kasra; Ostovaneh, Mohammad Reza; Ambale Venkatesh, Bharath et al. (2018) Left Ventricular Hypertrophy and Remodeling and Risk of Cognitive Impairment and Dementia: MESA (Multi-Ethnic Study of Atherosclerosis). Hypertension 71:429-436 |
| Ambale-Venkatesh, Bharath; Yang, Xiaoying; Wu, Colin O et al. (2017) Cardiovascular Event Prediction by Machine Learning: The Multi-Ethnic Study of Atherosclerosis. Circ Res 121:1092-1101 |
| Nacif, Marcelo S; Almeida, Andre L C; Young, Alistair A et al. (2017) Three-Dimensional Volumetric Assessment of Diastolic Function by Cardiac Magnetic Resonance Imaging: The Multi-Ethnic Study of Atherosclerosis (MESA). Arq Bras Cardiol 108:552-563 |
| Ohyama, Yoshiaki; Ambale-Venkatesh, Bharath; Noda, Chikara et al. (2017) Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events: The MESA (Multi-Ethnic Study of Atherosclerosis). Hypertension 70:524-530 |
| Gjesdal, Ola; Yoneyama, Kihei; Mewton, Nathan et al. (2016) Reduced long axis strain is associated with heart failure and cardiovascular events in the multi-ethnic study of Atherosclerosis. J Magn Reson Imaging 44:178-85 |
| Jenny, Nancy Swords; Olson, Nels C; Allison, Matthew A et al. (2016) Biomarkers of Key Biological Pathways in CVD. Glob Heart 11:327-336.e3 |
| Polak, Joseph F; O'Leary, Daniel H (2016) Carotid Intima-Media Thickness as Surrogate for and Predictor of CVD. Glob Heart 11:295-312.e3 |
| Criqui, Michael H; Aboyans, Victor; Allison, Matthew A et al. (2016) Peripheral Artery Disease and Aortic Disease. Glob Heart 11:313-326 |
| Blaha, Michael J; Yeboah, Joseph; Al Rifai, Mahmoud et al. (2016) Providing Evidence for Subclinical CVD in Risk Assessment. Glob Heart 11:275-285 |
Showing the most recent 10 out of 58 publications
