Abstract

? Real time trans-thoracic volumetric scanning, using 2-D array transducers based on Duke University designs, offers potential to increase the accuracy of cardiac measurements such as ventricular volumes and improve the diagnosis of coronary heart disease. The objective of this proposal is to extend the advances of real time volumetric scanning to transesophageal endoscopes, surgical endoscopes for applications in minimally invasive cardiac surgery. In this research, we will develop new 2D array transducers including cylindrical and hemispherical curvilinear probes operating from 5-10 MHz which produce a panoramic 3-D field of view approaching 1800. We will also develop an intracardiac catheter which combines 3-D ultrasound imaging and endocardial ultrasound thermal ablation system integrated within a single catheter delivery device for applications to the cardiac arrhythmias and interventional cardiology. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL072840-03
Application #
6884024
Study Section
Special Emphasis Panel (ZRG1-SSS-X (10))
Program Officer
Buxton, Denis B
Project Start
2003-05-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
3
Fiscal Year
2005
Total Cost
$385,000
Indirect Cost

  Institution

Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Smith, Stephen W; Ivancevich, Nikolas M; Lindsey, Brooks D et al. (2009) The ultrasound brain helmet: feasibility study of multiple simultaneous 3D scans of cerebral vasculature. Ultrasound Med Biol 35:329-38
Ivancevich, Nikolas M; Pinton, Gianmarco F; Nicoletto, Heather A et al. (2008) Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction. Ultrasound Med Biol 34:1387-95
Light, Edward D; Angle, John F; Smith, Stephen W (2008) Real-time 3-D ultrasound guidance of interventional devices. IEEE Trans Ultrason Ferroelectr Freq Control 55:2066-78
Light, Edward D; Mukundan, Srinivasan; Wolf, Patrick D et al. (2007) Real-time 3-d intracranial ultrasound with an endoscopic matrix array transducer. Ultrasound Med Biol 33:1277-84
Pua, Eric C; Idriss, Salim F; Wolf, Patrick D et al. (2007) Real-time three-dimensional transesophageal echocardiography for guiding interventional electrophysiology: feasibility study. Ultrason Imaging 29:182-94
Pua, Eric C; Qiu, Yupeng; Smith, S W (2007) Integrated endoscope for real-time 3D ultrasound imaging and hyperthermia: feasibility study. Ultrason Imaging 29:1-14
Noble, Joanna R; Fronheiser, Matthew P; Smith, Stephen W (2006) Real-time stereo 3D ultrasound. Ultrason Imaging 28:245-54
Pua, Eric C; Fronheiser, Matthew P; Noble, Joanna R et al. (2006) 3-D ultrasound guidance of surgical robotics: a feasibility study. IEEE Trans Ultrason Ferroelectr Freq Control 53:1999-2008
Light, Edward D; Idriss, Salim F; Sullivan, Kathryn F et al. (2005) Real-time 3D laparoscopic ultrasonography. Ultrason Imaging 27:129-44
Gentry, Kenneth L; Smith, Stephen W (2004) Integrated catheter for 3-D intracardiac echocardiography and ultrasound ablation. IEEE Trans Ultrason Ferroelectr Freq Control 51:800-8

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