The incidence of type 2 diabetes mellitus (DM) continues to rise rapidly in the United States. During heat stress, individuals with type 2 DM appear to be at increased risk for development of heat illness. In humans, cutaneous vasodilator responsiveness to thermal stress is essential for the heat dissipation necessary to maintain internal body temperature during heat exposure or exercise. Cutaneous vascular complications of type 2 DM are well-recognized, and local vasodilator responsiveness appears to be impaired in this disease, although the mechanisms for these changes are not clear. Impaired thermoregulatory vasodilation in the skin of patients with type 2 DM could contribute to the increased risk of heat illness; however, no information exists regarding cutaneous vasodilation during whole body heat stress in patients with type 2 DM. In this application, we propose to use laser-Doppler measurements of skin blood flow, measurements of forearm blood flow by venous occlusion plethysmography, and local pharmacological blockade in combination with (a) direct (local) heating of the skin, and (b) whole-body heating in patients with type 2 DM and age-matched controls to address the following specific aims: (1) To test whether local thermal control of cutaneous vasodilation is diminished with type 2 DM. (2) To quantify changes in contributions of sensory nerve and nitric oxide mechanisms to local warming vasodilation in type 2 DM. (3) To test whether the reflex cutaneous vasodilator response to whole body heat stress is diminished with type 2 DM. (4) To test whether any changes in reflex vasodilation during whole body heat stress are due to decreased sympathetic active vasodilation in the skin, and whether a decreased contribution of nitric oxide is involved. Our assessment of four mechanisms of skin blood flow regulation in patients with type 2 DM compared to control subjects matched for age and body size will provide important insight into potentially dangerous impairments of thermoregulatory control of skin blood flow in these patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL073884-03
Application #
7008863
Study Section
Respiratory Physiology Study Section (RESP)
Program Officer
Rabadan-Diehl, Cristina
Project Start
2004-03-10
Project End
2008-02-29
Budget Start
2006-03-01
Budget End
2007-02-28
Support Year
3
Fiscal Year
2006
Total Cost
$288,068
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Wieland, Mark L; Weis, Jennifer A; Palmer, Tiffany et al. (2012) Physical activity and nutrition among immigrant and refugee women: a community-based participatory research approach. Womens Health Issues 22:e225-32
Wieland, Mark L; Weis, Jennifer A; Olney, Marilynn W et al. (2011) Screening for tuberculosis at an adult education center: results of a community-based participatory process. Am J Public Health 101:1264-7
Strom, Nicholas A; Meuchel, Lucas W; Mundy, Daniel W et al. (2011) Cutaneous sympathetic neural responses to body cooling in type 2 diabetes mellitus. Auton Neurosci 159:15-9
Amico, K L; Wieland, M L; Weis, J A et al. (2011) Capacity building through focus group training in community-based participatory research. Educ Health (Abingdon) 24:638
Charkoudian, Nisha (2010) Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans. J Appl Physiol (1985) 109:1221-8
Strom, Nicholas A; Sawyer, Jessica R; Roberts, Shelly K et al. (2010) Local sensory nerve control of skin blood flow during local warming in type 2 diabetes mellitus. J Appl Physiol 108:293-7
Sokolnicki, Lynn A; Strom, Nicholas A; Roberts, Shelly K et al. (2009) Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus. J Appl Physiol 106:566-70
Wallin, B Gunnar; Charkoudian, Nisha (2007) Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity. Muscle Nerve 36:595-614
Sokolnicki, Lynn A; Roberts, Shelly K; Wilkins, Bradley W et al. (2007) Contribution of nitric oxide to cutaneous microvascular dilation in individuals with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 292:E314-8
Wick, Diane E; Roberts, Shelly K; Basu, Ananda et al. (2006) Delayed threshold for active cutaneous vasodilation in patients with Type 2 diabetes mellitus. J Appl Physiol 100:637-41

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