In epidemiologic studies, associations of cardiovascular risk with individual and neighborhood socioeconomic characteristics tend to persist after adjustment for established cardiovascular risk factors suggesting that other mediators may be involved. However, evidence regarding what these mediators may be is largely absent. Elucidating the reasons for these persistent socioeconomic differences may enhance our ability to reduce these differentials and will contribute to our understanding of the causes of cardiovascular disease generally. Two biological processes, inflammation and hemostasis, have recently emerged as potentially important in the development of atherosclerosis and the precipitation of clinical cardiovascular events. Both processes have also been recently linked to psychosocial factors and stress. However, studies investigating social gradients in inflammation and hemostasis remain rare. In addition, the relation of psychosocial factors and biological markers of the stress response to inflammation and hemostasis have not been examined in large population-based studies. The overall goal of this epidemiologic study is to advance our understanding of how inflammation, hemostasis, and stress may contribute to neighborhood and individual-level socioeconomic differences in cardiovascular risk. Using newly collected data linked to an ongoing epidemiologic study of atherosclerosis (the Multi-Ethnic Study of Atherosclerosis (MESA)), we propose to investigate (1) associations of neighborhood and individual-level socioeconomic indicators with markers of inflammation and hemostasis; (2) associations of individual-level psychosocial factors and sources of chronic stress (at the individual and neighborhood level) with inflammatory markers and hemostasis; and (3) the relationship between biological markers of the stress response (such as cortisol and adrenaline/noradrenaline) and inflammation and hemostasis). Project aims will be achieved by linking MESA data to newly-collected data on neighborhood characteristics and biomarkers of inflammation, hemostasis and the stress response in MESA participants. The project is innovative in that it will span and link three levels: the social/environmental level (neighborhood characteristics and social position), the behavioral/psychological level (behavioral and psychosocial factors), and the biological level (inflammation, hemostasis, and stress hormones). The study will provide a unique opportunity to elucidate the links between socioeconomic factors, stress, inflammation and hemostasis in a large and diverse population-based sample.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL076831-02
Application #
6943440
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Wei, Gina
Project Start
2004-09-01
Project End
2008-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
2
Fiscal Year
2005
Total Cost
$781,008
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lê-Scherban, Félice; Brenner, Allison B; Hicken, Margaret T et al. (2018) Child and Adult Socioeconomic Status and the Cortisol Response to Acute Stress: Evidence From the Multi-Ethnic Study of Atherosclerosis. Psychosom Med 80:184-192
Smith, Jennifer A; Zhao, Wei; Wang, Xu et al. (2017) Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics 12:662-673
Novak, Nicole L; Wang, Xu; Clarke, Philippa J et al. (2017) Diurnal salivary cortisol and nativity/duration of residence in Latinos: The Multi-Ethnic Study of Atherosclerosis. Psychoneuroendocrinology 85:179-189
Blaha, Michael J; Yeboah, Joseph; Al Rifai, Mahmoud et al. (2016) Providing Evidence for Subclinical CVD in Risk Assessment. Glob Heart 11:275-285
Jenny, Nancy Swords; Olson, Nels C; Allison, Matthew A et al. (2016) Biomarkers of Key Biological Pathways in CVD. Glob Heart 11:327-336.e3
Polak, Joseph F; O'Leary, Daniel H (2016) Carotid Intima-Media Thickness as Surrogate for and Predictor of CVD. Glob Heart 11:295-312.e3
Criqui, Michael H; Aboyans, Victor; Allison, Matthew A et al. (2016) Peripheral Artery Disease and Aortic Disease. Glob Heart 11:313-326
Hajat, Anjum; Moore, Kari; Do, D Phuong et al. (2015) Examining the cross-sectional and longitudinal association between diurnal cortisol and neighborhood characteristics: Evidence from the multi-ethnic study of atherosclerosis. Health Place 34:199-206
Needham, Belinda L; Smith, Jennifer A; Zhao, Wei et al. (2015) Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics 10:958-69
Castro-Diehl, Cecilia; Diez Roux, Ana V; Redline, Susan et al. (2015) Association of Sleep Duration and Quality With Alterations in the Hypothalamic-Pituitary Adrenocortical Axis: The Multi-Ethnic Study of Atherosclerosis (MESA). J Clin Endocrinol Metab 100:3149-58

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