Exposure to stress can have long-term physiological and psychological consequences. The current proposal will examine the effects of prior exposure to social stress on the histological, physiological and behavioral consequences of cardiac arrest and cardiopulmonary resuscitation (CPR). In addition, stress-induced alterations in corticosteroid responses will be examined as one of the mechanisms through which social cues can influence outcome in our mouse model of cardiac arrest. The data collected as part of this proposal will increase our understanding of the basic pathophysiological mechanism of global ischemia and the roles that social interaction and the hypothalamic-pituitary-adrenal axis play in influencing post-cardiac arrest neuronal death, neuronal restructuring, anxiogenic-like behavior and cognitive function. Ultimately, understanding the factors that modulate neurotoxicity and behavioral outcomes may facilitate the development of therapeutic approaches for the prevention and treatment of cerebral ischemia. Taken together, the proposed studies will provide a neurobiological foundation on which to study the effects of stress on cardiac arrest/CPR outcome, and may provide insights into the mechanisms underlying individual differences in outcome following an ischemic event.
| Norman, Greg J; Morris, John S; Karelina, Kate et al. (2011) Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic ?7 nicotinic receptors. J Neurosci 31:3446-52 |
| Karelina, Kate; Stuller, Kathleen A; Jarrett, Brant et al. (2011) Oxytocin mediates social neuroprotection after cerebral ischemia. Stroke 42:3606-11 |
| Karelina, Kate; DeVries, A Courtney (2011) Modeling social influences on human health. Psychosom Med 73:67-74 |
| Norman, Greg J; Zhang, Ning; Morris, John S et al. (2010) Social interaction modulates autonomic, inflammatory, and depressive-like responses to cardiac arrest and cardiopulmonary resuscitation. Proc Natl Acad Sci U S A 107:16342-7 |
| Neigh, Gretchen N; Karelina, Kate; Glasper, Erica R et al. (2009) Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline. Stroke 40:3601-7 |
| Weil, Zachary M; Karelina, Kate; Su, Alan J et al. (2009) Time-of-day determines neuronal damage and mortality after cardiac arrest. Neurobiol Dis 36:352-60 |
| Weil, Zachary M; Norman, Greg J; DeVries, A Courtney et al. (2009) Photoperiod alters autonomic regulation of the heart. Proc Natl Acad Sci U S A 106:4525-30 |
| Karelina, Kate; Norman, Greg J; Zhang, Ning et al. (2009) Social isolation alters neuroinflammatory response to stroke. Proc Natl Acad Sci U S A 106:5895-900 |
| Neigh, Gretchen N; Karelina, Kate; Zhang, Ning et al. (2009) Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis. J Cereb Blood Flow Metab 29:1673-82 |
| Weil, Zachary M; Norman, Greg J; Karelina, Kate et al. (2009) Sleep deprivation attenuates inflammatory responses and ischemic cell death. Exp Neurol 218:129-36 |
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