Intravascular ultrasound (IVUS) imaging has become an essential imaging modality for the effective diagnosis and treatment of cardiovascular diseases during the past decade due to innovative applications of piezoelectric transducer technology. The limitations of the same piezoelectric transducers have impeded the improvement of IVUS for emerging clinically important applications such as forward viewing arrays for guiding interventions, high resolution imaging of arterial structure such as vulnerable plaque, vasa vasorum and fibrous cap, and for implementation of techniques such as harmonic imaging of the arterial tissue and of the contrast agents. In this project, we plan to proceed on two parallel paths with immediate and long term impact. On one path we propose to develop low cost, low profile, broadband CMUT-based IVUS probes with 2 to 4 single chip annular arrays to generate M-mode slices of coronary arteries around 25MHz center frequency and 100% fractional bandwidth. These arrays will improve the crossing capabilities of IVUS catheters and can be potentially scanned and pulled back manually to generate images during interventions. Implementation and testing of these probes will enhance our understanding of issues related to the manufacturing of CMUT-based IVUS arrays and result in possible design improvements. In parallel with this effort, the second path aims to explore innovations in CMUT design to enable novel IVUS applications. CMUTs with dual electrode structures not only improve the pressure output for high penetration depth and tissue harmonic generation, but these transducers may simplify the probe electronics by removing the need for transmit-receive switching. Dual electrode CMUT structure coupled with mass loaded CMUT membranes opens up other possibilities. With enhanced sensitivity to selected harmonics based on these novel CMUTs, the proposed research may advance medical ultrasound imaging in general generating an impact much broader than IVUS. ? ?
| Gurun, Gokce; Hochman, Michael; Hasler, Paul et al. (2012) Thermal-mechanical-noise-based CMUT characterization and sensing. IEEE Trans Ultrason Ferroelectr Freq Control 59:1267-75 |
| Satir, Sarp; Degertekin, F Levent (2012) Harmonic reduction in capacitive micromachined ultrasonic transducers by gap feedback linearization. IEEE Trans Ultrason Ferroelectr Freq Control 59:50-9 |
| Gurun, Gokce; Zahorian, Jaime S; Sisman, Alper et al. (2012) An analog integrated circuit beamformer for high-frequency medical ultrasound imaging. IEEE Trans Biomed Circuits Syst 6:454-67 |
| Tekes, Coskun; Zahorian, Jaime; Gurun, Gokce et al. (2012) Volumetric imaging using single chip integrated CMUT-on-CMOS IVUS array. Conf Proc IEEE Eng Med Biol Soc 2012:3195-8 |
| Perng, John Kangchun; Lee, Seungjun; Kundu, Kousik et al. (2012) Ultrasound imaging of oxidative stress in vivo with chemically-generated gas microbubbles. Ann Biomed Eng 40:2059-68 |
| Tekes, Coskun; Karaman, Mustafa; Degertekin, F Levent (2011) Optimizing circular ring arrays for forward-looking IVUS imaging. IEEE Trans Ultrason Ferroelectr Freq Control 58:2596-607 |
| Gurun, Gokce; Hasler, Paul; Degertekin, F (2011) Front-end receiver electronics for high-frequency monolithic CMUT-on-CMOS imaging arrays. IEEE Trans Ultrason Ferroelectr Freq Control 58:1658-68 |
| Zahorian, Jaime; Hochman, Michael; Xu, Toby et al. (2011) Monolithic CMUT-on-CMOS integration for intravascular ultrasound applications. IEEE Trans Ultrason Ferroelectr Freq Control 58:2659-67 |
| Guldiken, Rasim O; Zahorian, Jaime; Yamaner, F Y et al. (2009) Dual-electrode CMUT with non-uniform membranes for high electromechanical coupling coefficient and high bandwidth operation. IEEE Trans Ultrason Ferroelectr Freq Control 56:1270-6 |
| Guldiken, Rasim O; Balantekin, Mujdat; Zahorian, Jaime et al. (2008) Characterization of dual-electrode CMUTs: demonstration of improved receive performance and pulse echo operation with dynamic membrane shaping. IEEE Trans Ultrason Ferroelectr Freq Control 55:2336-44 |
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