Principal Investigator/Program Director (Last, first, middle): Boiselle, Phillip, Michael RESEARCH &RELATED Other Project Information 1. * Are Human Subjects Involved? l Yes m No 1.a. If YES to Human Subjects Is the IRB review Pending? l Yes m No IRB Approval Date: Exemption Number: 1 2 3 4 5 6 Human Subject Assurance Number 00003245 2. * Are Vertebrate Animals Used? m Yes l No 2.a. If YES to Vertebrate Animals Is the IACUC review Pending? m Yes m No IACUC Approval Date: Animal Welfare Assurance Number 3. * Is proprietary/privileged information m Yes l No included in the application? 4.a.* Does this project have an actual or potential impact on m Yes l No the environment? 4.b. If yes, please explain: 4.c. If this project has an actual or potential impact on the environment, has an exemption been authorized or an environmental assessment (EA) or environmental impact statement (EIS) been performed? m Yes m No 4.d. If yes, please explain: 5.a.* Does this project involve activities outside the U.S. or m Yes l No partnership with International Collaborators? 5.b. If yes, identify countries: 5.c. Optional Explanation: 6. * Project Summary/Abstract 369-Abstract.pdf Mime Type: application/pdf 7. * Project Narrative 9550-Narrative.pdf Mime Type: application/pdf 8. Bibliography &References Cited 8818-References.pdf Mime Type: application/pdf 9. Facilities &Other Resources 3884-RESOURCES.pdf Mime Type: application/pdf 10. Equipment 6624-EQUIPMENT.pdf Mime Type: application/pdf Tracking Number: Other Information Page 5 OMB Number: 4040-0001 Expiration Date: 04/30/2008 Principal Investigator/Program Director (Last, first, middle): Boiselle, Phillip, Michael Abstract: The broad, long-term goals of the proposed study are to determine the prevalence and natural history of tracheomalacia among patients with chronic obstructive pulmonary disease (COPD) and to establish the role of a novel CT method in guiding therapy and assessing response to intervention. This work also has the potential to reduce morbidity among patients with coexisting COPD and tracheomalacia. Chronic cough is the fifth most common symptom for which patients seek medical care in the United States, accounting for more than 30 million office visits per year. Acquired tracheomalacia, a condition defined by excessive expiratory collapse of the trachea due to weakness of the airway walls and/or supporting cartilage, is a relatively common but frequently overlooked cause of chronic cough. Tracheomalacia is associated with a variety of risk factors, most notably COPD. Importantly, tracheomalacia can cause significant respiratory morbidity if left untreated, and it may rarely be fatal. Our preliminary studies demonstrate that paired inspiratory-dynamic expiratory CT is a highly accurate, noninvasive method for diagnosing tracheomalacia, with comparable accuracy to the current gold standard of bronchoscopy, an invasive procedure. We propose a diagnostic study which will be a collaborative, multidisciplinary effort by the departments of radiology, pulmonary medicine, thoracic surgery, pathology, and anesthesia at Beth Israel Deaconess Medical Center and Harvard Medical School, a center that has established expertise in the diagnosis and treatment of this disorder. We propose the following specific aims:
Aim 1 : Determine the prevalence of tracheomalacia among patients with COPD;
Aim 2 : Identify physiological and clinical parameters that are predictive of tracheomalacia in patients with COPD;
Aim 3 : Determine the natural history of tracheomalacia in the absence of intervention among subjects who are asymptomatic or mildly symptomatic;
and Aim 4 : Identify factors that are predictive of a positive response to intervention by assessing longitudinal changes in
| O'Donnell, C R; Bankier, A A; O'Donnell, D H et al. (2014) Static end-expiratory and dynamic forced expiratory tracheal collapse in COPD. Clin Radiol 69:357-62 |
| Boiselle, Phillip M; Litmanovich, Diana E; Michaud, Gaetane et al. (2013) Dynamic expiratory tracheal collapse in morbidly obese COPD patients. COPD 10:604-10 |
| Boiselle, Phillip M; Michaud, Gaetane; Roberts, David H et al. (2012) Dynamic expiratory tracheal collapse in COPD: correlation with clinical and physiologic parameters. Chest 142:1539-1544 |
| O'Donnell, Carl R; Litmanovich, Diana; Loring, Stephen H et al. (2012) Age and sex dependence of forced expiratory central airway collapse in healthy volunteers. Chest 142:168-174 |
| Ridge, Carole A; O'donnell, Carl R; Lee, Edward Y et al. (2011) Tracheobronchomalacia: current concepts and controversies. J Thorac Imaging 26:278-89 |
| Boiselle, Phillip M; O'Donnell, Carl R; Loring, Stephen H et al. (2010) Reproducibility of forced expiratory tracheal collapse: assessment with MDCT in healthy volunteers. Acad Radiol 17:1186-9 |
| Boiselle, Phillip M; O'Donnell, Carl R; Bankier, Alexander A et al. (2009) Tracheal collapsibility in healthy volunteers during forced expiration: assessment with multidetector CT. Radiology 252:255-62 |
