Abstract

It has been well documented that cardiovascular complications of diabetes account for 75% of all deaths in patients with type 2 diabetes. Hypertension occurs approximately twice as frequently in patients with diabetes compared with non-diabetic individuals. Although it is clear that the state of diabetes confers an increased risk of cardiovascular events, the mechanism by which metabolic perturbations influence vascular function and structure remain to be further defined. Emerging data suggest that peroxisome proliferator-activated receptor-3 (PPAR3) and angiotensin II (Ang II) type 1 receptor (AT1R) are two critical determinants that may provide functional links between obesity/diabetes, hypertension and cardiovascular disease (CVD). Recently, we have reported the identification of nitroalkene derivatives of linoleic acid (LNO2) and oleic acid (OA-NO2) with concentrations exceeding 1

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL089544-02S1
Application #
7995423
Study Section
Hypertension and Microcirculation Study Section (HM)
Program Officer
Mcdonald, Cheryl
Project Start
2008-04-01
Project End
2013-03-31
Budget Start
2009-12-15
Budget End
2010-03-31
Support Year
2
Fiscal Year
2010
Total Cost
$24,783
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Chang, Lin; Xiong, Wenhao; Zhao, Xiangjie et al. (2018) Bmal1 in Perivascular Adipose Tissue Regulates Resting-Phase Blood Pressure Through Transcriptional Regulation of Angiotensinogen. Circulation 138:67-79
Fan, Jianglin; Kitajima, Shuji; Watanabe, Teruo et al. (2015) Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine. Pharmacol Ther 146:104-19
Yin, Ke-Jie; Hamblin, Milton; Fan, Yanbo et al. (2015) Krüpple-like factors in the central nervous system: novel mediators in stroke. Metab Brain Dis 30:401-10
Brown, Nicholas K; Zhou, Zhou; Zhang, Jifeng et al. (2014) Perivascular adipose tissue in vascular function and disease: a review of current research and animal models. Arterioscler Thromb Vasc Biol 34:1621-30
Liu, Ling; Zhou, Zhou; Huang, Shengping et al. (2013) Zc3h12c inhibits vascular inflammation by repressing NF-ýýB activation and pro-inflammatory gene expression in endothelial cells. Biochem J 451:55-60
Wang, Yao; Niimi, Manabu; Nishijima, Kazutoshi et al. (2013) Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits. Arterioscler Thromb Vasc Biol 33:224-31
Zhou, Zhou; Miao, Ruidong; Huang, Shengping et al. (2013) MCPIP1 deficiency in mice results in severe anemia related to autoimmune mechanisms. PLoS One 8:e82542
Guo, Yanhong; Fan, Yanbo; Zhang, Jifeng et al. (2013) Peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells. J Biol Chem 288:4625-36
Huang, Shengping; Miao, Ruidong; Zhou, Zhou et al. (2013) MCPIP1 negatively regulates toll-like receptor 4 signaling and protects mice from LPS-induced septic shock. Cell Signal 25:1228-34
Yin, Ke-Jie; Hamblin, Milton; Chen, Y Eugene (2013) Angiogenesis-Regulating microRNAs and Ischemic Stroke. Curr Vasc Pharmacol :

Showing the most recent 10 out of 47 publications