After two decades of emphasis on valve replacement, cardiac surgeons have been gradually turning to mitral valve repair. MV repair, rather than replacement, maintains better ventricular mechanics and fewer complications, such as endocarditis, thromboembolism, and anticoagulant-related hemorrhage. Unfortunately, recent long term studies using more rigorous definitions of failure have identified less optimistic result for repair durability; bringing into question such aggressive surgical practice and suggesting that repair techniques though mature can be improved upon. In most cases, failures were a result of disruption at the leaflet, chordal, or annular suture lines. These failure modes suggest excessive tissue stress and the resulting strain induced tissue damage as an etiologic factor. Thus, there has been growing interest in developing more robust repair strategies for patients with IMR. Promising concepts include leaflet augmentation to restore leaflet mobility, and saddle shaped annuloplasty to restore normal annular shape. If designed correctly, leaflet augmentation techniques can alleviate chordal-leaflet tethering and reduce leaflet stress by promoting leaflet curvature and coaptation. Leaflet augmentation will also allow the placement of larger annuloplasty rings that should reduce annular-annuloplasty ring separation forces. We thus hypothesize that IMR repair techniques that reinstate normal annular geometry (size and shape) and restore mobile leaflet tissue will result in reduced annular and chordal force distribution compared with undersized flat annuloplasty alone. This in turn will lead to restoration of homeostatic normal tissue stress levels and MVIC biosynthetic responses, ultimately leading to improved repair durability.

Public Health Relevance

After two decades of emphasis on valve replacement, cardiac surgeons have been gradually turning to mitral valve repair. Thus, we plan on developing a comprehensive model to optimize the restoration of homeostatic normal tissue stress levels leading to improved valve repair durability.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL119297-03
Application #
8869031
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Evans, Frank
Project Start
2013-09-01
Project End
2016-05-31
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
3
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
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Khalighi, Amir H; Drach, Andrew; Bloodworth 4th, Charles H et al. (2017) Mitral Valve Chordae Tendineae: Topological and Geometrical Characterization. Ann Biomed Eng 45:378-393
Goth, Will; Lesicko, John; Sacks, Michael S et al. (2016) Optical-Based Analysis of Soft Tissue Structures. Annu Rev Biomed Eng 18:357-85

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