A longstanding informatics challenge has been to develop efficient mechanisms whereby valid medical knowledge?such as that contained in practice guidelines?can be operationalized in systems that support decision making by clinicians. However, a frustrating impediment to the satisfaction of this goal has been the difficulty of translation of guideline knowledge into computable formats. In this competing renewal application we propose a research program that will extend successful accomplishments. 1. Recognizing that vague and ambiguous recommendations impede both guideline implementation and adherence, we will model and characterize the forms of ambiguity and vagueness that are prevalent in guideline statements, ascertain the degree to which such statements lead to clinical uncertainty, and identify methods to diminish this uncertainty. 2. In collaboration with the American Academy of Pediatrics and the American Academy of Family Physicians, we will develop, install, and evaluate software tools that support efficient authoring of scientifically valid and implementable guidelines. Working with the national professional societies offers an opportunity to move the tools and techniques developed in the last grant period into the real world where they will be evaluated and iteratively improved. 3. We will facilitate implementation of guideline knowledge by developing tools to help translate natural language recommendations into formal rules and apply a framework based on action-types to design reusable implementation strategies that can be used at national and local levels. 4. We will modify and further extend the Guideline Elements Model to accommodate concepts that are critical for guideline document modeling, authoring, and implementation activities. We will create an XML Schema and provide capabilities to current users to assure their GEM files remain compatible. Furthermore, we will submit the new model as a proposed standard to HL7 and/or ASTM. A systematic process for translating guideline knowledge into operational decision support systems can have substantial benefits for delivery of high-quality, evidence based health care. In addition, the proposed activities focus on systems that will preferentially impact children?a particularly vulnerable population.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Project (R01)
Project #
3R01LM007199-03S1
Application #
7356160
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Program Officer
Sim, Hua-Chuan
Project Start
2002-03-01
Project End
2007-05-31
Budget Start
2007-03-01
Budget End
2007-05-31
Support Year
3
Fiscal Year
2007
Total Cost
$84,611
Indirect Cost
Name
Yale University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Shiffman, Richard N; Michel, George; Rosenfeld, Richard M et al. (2012) Building better guidelines with BRIDGE-Wiz: development and evaluation of a software assistant to promote clarity, transparency, and implementability. J Am Med Inform Assoc 19:94-101
Hajizadeh, Negin; Kashyap, Nitu; Michel, George et al. (2011) GEM at 10: a decade's experience with the Guideline Elements Model. AMIA Annu Symp Proc 2011:520-8
Lomotan, E A; Michel, G; Lin, Z et al. (2010) How ""should"" we write guideline recommendations? Interpretation of deontic terminology in clinical practice guidelines: survey of the health services community. Qual Saf Health Care 19:509-13
Scotch, Matthew; Duggal, Mona; Brandt, Cynthia et al. (2010) Use of statistical analysis in the biomedical informatics literature. J Am Med Inform Assoc 17:3-5
Hussain, Tamseela; Bell, Brian; Brandt, Cynthia et al. (2010) Using VistA electronic medical record data extracts to calculate the waiting time for total knee arthroplasty. J Arthroplasty 25:213-5
Rosenfeld, Richard M; Shiffman, Richard N (2009) Clinical practice guideline development manual: a quality-driven approach for translating evidence into action. Otolaryngol Head Neck Surg 140:S1-43
Hsiao, Allen L; Shiffman, Richard N (2009) Dropping the baton during the handoff from emergency department to primary care: pediatric asthma continuity errors. Jt Comm J Qual Patient Saf 35:467-74
Tran, Nam; Michel, George; Krauthammer, Michael et al. (2009) Embedding the guideline elements model in web ontology language. AMIA Annu Symp Proc 2009:645-9
Hussain, Tamseela; Michel, George; Shiffman, Richard N (2009) The Yale Guideline Recommendation Corpus: a representative sample of the knowledge content of guidelines. Int J Med Inform 78:354-63
Michel, George; Marcy, Theodore; Shiffman, Richard N (2005) A wireless, handheld decision support system to promote smoking cessation in primary care. AMIA Annu Symp Proc :530-4

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