: Despite the availability of evidence-based treatment models for sleep apnea, the majority of at-risk individuals in underserved US communities remains undiagnosed. This is a major public health concern since untreated sleep apnea is linked to cardiovascular disease and components of the metabolic syndrome. Blacks endorse a disproportionate burden of sleep apnea-related morbidity. Yet, few black patients adhere to recommended sleep apnea assessment by their physician, while most referred patients receive a diagnosis of sleep apnea. Maximizing the likelihood that black patients adhere to physician recommended sleep apnea assessment and treatment, thus reducing cardio-metabolic morbidity, is the focus of this proposal.
The aims are consistent with NIH program announcement (RFA-MD-09-004), soliciting proposals to study chronic diseases that disproportionately affect underserved, and low-income ethnic minorities. In a two-arm randomized controlled trial, we will assess effectiveness of a culturally and linguistically tailored telephone intervention in increasing adherence to recommended assessment and treatment of sleep apnea. Telephone interventions will be delivered by trained, quality-controlled Health Educators. The sampling frame will consist of 340 black patients enrolled in the Metabolic Syndrome Outcome Study (MetSOS), a Brooklyn-based study of patients with cardio-metabolic diseases. Among patients with metabolic syndrome and are at high risk for sleep apnea, those randomized to the intervention arm, compared with those randomized to the attention-control arm, will have: 1) greater adherence to physician recommended sleep apnea assessment at 6 months and 2) greater adherence to treatment with Continuous Positive Airway Pressure post diagnosis;3) effects of the intervention on adherence rates will be sustained 6 months after discontinuing active interventions, and treatment will improve components of the metabolic syndrome (waist circumference, blood pressure, lipid level, and fasting plasma glucose;and 4) patients'knowledge about sleep, self-efficacy, readiness, trust/rapport with the Health Educator will mediate intervention effects on study outcomes. We expect that our intervention will serve as an alternative model of promoting awareness of sleep apnea and enhancing adherence to recommended care among blacks nationwide.

Public Health Relevance

This proposal will test the effectiveness of a tailored telephone intervention in increasing adherence to recommended sleep apnea assessment and treatment among black patients at high risk for sleep apnea. The sampling frame will consist of 340 patients enrolled in the Metabolic Syndrome Outcome Study, a Brooklyn-based study of patients with cardio-metabolic diseases. We expect that our intervention will serve as an alternative model of promoting awareness of sleep apnea and enhancing adherence to recommended care among blacks nationwide.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Project (R01)
Project #
5R01MD004113-02
Application #
7938863
Study Section
Special Emphasis Panel (ZMD1-PA (R4))
Program Officer
Alvidrez, Jennifer L
Project Start
2009-09-25
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
2
Fiscal Year
2010
Total Cost
$415,246
Indirect Cost
Name
Suny Downstate Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
040796328
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Williams, Natasha J; Castor, Chimene; Seixas, Azizi et al. (2018) Sleep Disorders and Symptoms in Blacks with Metabolic Syndrome: The Metabolic Syndrome Outcome Study (MetSO). Ethn Dis 28:193-200
Jean-Louis, Girardin; Newsome, Valerie; Williams, Natasha J et al. (2017) Tailored Behavioral Intervention Among Blacks With Metabolic Syndrome and Sleep Apnea: Results of the MetSO Trial. Sleep 40:
Rogers, April; Necola, Olivia; Sexias, Azizi et al. (2016) Resistant Hypertension and Sleep Duration among Blacks with Metabolic Syndrome MetSO. J Sleep Disord Treat Care 5:
Ravenell, Joseph; Seixas, Azizi; Rosenthal, Diana Margot et al. (2016) Effect of birthplace on cardiometabolic risk among blacks in the Metabolic Syndrome Outcome Study (MetSO). Diabetol Metab Syndr 8:14
Grandner, Michael A; Williams, Natasha J; Knutson, Kristen L et al. (2016) Sleep disparity, race/ethnicity, and socioeconomic position. Sleep Med 18:7-18
Williams, Natasha J; Jean-Louis, Girardin; Ravenell, Joeseph et al. (2016) A community-oriented framework to increase screening and treatment of obstructive sleep apnea among blacks. Sleep Med 18:82-7
Williams, Natasha J; Grandner, Michael A; Wallace, Douglas M et al. (2016) Social and behavioral predictors of insufficient sleep among African Americans and Caucasians. Sleep Med 18:103-7
Seixas, A; Ravenell, J; Williams, N J et al. (2016) Uncontrolled blood pressure and risk of sleep apnea among blacks: findings from the Metabolic Syndrome Outcome (MetSO) study. J Hum Hypertens 30:149-52
Ceïde, Mirnova E; Pandey, Abhishek; Ravenell, Joe et al. (2015) Associations of Short Sleep and Shift Work Status with Hypertension among Black and White Americans. Int J Hypertens 2015:697275
Williams, Natasha J; Nunes, João V; Zizi, Ferdinand et al. (2015) Factors associated with referrals for obstructive sleep apnea evaluation among community physicians. J Clin Sleep Med 11:23-6

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