The goal is to further our knowledge about schizophrenia and other major psychoses by a prospective longitudinal investigation, addressing the following major hypotheses about thought disorder, psychosis, negative symptoms, prognosis, functioning and adjustment over time in schizophrenia: Hypothesis 1: Positive thought disorder and/or psychosis are persisting features for most schizophrenics. The hypothesis runs counter to recent proposals that schizophrenia is a vulnerability to episodes, and is not a continuous disorder. Hypothesis 2: Schizophrenics with persisting positive thought disorder are nuclear schizophrenics with poor clinical courses and downhill life adjustment. Hypothesis 3: Negative symptoms are as predictive as positive symptoms of poor outcome in schizophrenia. Hypothesis 4: Psychosis persists or recurs over time in schizophrenia, but remits in other psychotic disorders. Hypothesis 5: Contrary to recent hypotheses, modern-day schizophrenics still have relatively poor outcomes. Schizophrenics are vulnerable to a sustained disorder and not just to intermittent episodes. The research involves a multifaceted prospective, longitudinal investigation of thought disorders, psychotic symptoms, negative symptoms, and major components of adjustment over time, using a battery of structured interviews, performance tests, thought disorder measures, and behavioral ratings. A large sample of early young, schizophrenic, schizoaffective, manic, and nonpsychotic patients are being assessed longitudinally. Patients have been evaluated at the acute phase, during partial recovery, and are being followed up at various phases during the posthospital period, for disordered thinking, psychotic symptoms, and negative symptoms. They also are being assessed for neurotic and affective symptoms, rehospitalization, and social and work adjustment. The data are used to evaluate a number of theories about thought disorder, psychosis, negative symptoms, prognostic factors, and to assess the long-term clinical course and level of functioning and adjustment in modern-day schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH026341-16
Application #
3374962
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1986-09-25
Project End
1992-02-28
Budget Start
1991-04-01
Budget End
1992-02-28
Support Year
16
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Michael Reese Hospital
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60616
Harrow, M; Jobe, T H; Faull, R N (2014) Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study. Psychol Med 44:3007-16
Sarapas, Casey; Shankman, Stewart A; Harrow, Martin et al. (2013) Attention/processing speed prospectively predicts social impairment 18 years later in mood disorders. J Nerv Ment Dis 201:824-7
Goghari, V M; Harrow, M; Grossman, L S et al. (2013) A 20-year multi-follow-up of hallucinations in schizophrenia, other psychotic, and mood disorders. Psychol Med 43:1151-60
Harrow, Martin; Jobe, Thomas H (2013) Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery? Schizophr Bull 39:962-5
Sarapas, Casey; Shankman, Stewart A; Harrow, Martin et al. (2012) Parsing trait and state effects of depression severity on neurocognition: Evidence from a 26-year longitudinal study. J Abnorm Psychol 121:830-7
Kaplan, Kalman J; Harrow, Martin; Faull, Robert N (2012) Are there gender-specific risk factors for suicidal activity among patients with schizophrenia and depression? Suicide Life Threat Behav 42:614-27
Harrow, M; Jobe, T H; Faull, R N (2012) Do all schizophrenia patients need antipsychotic treatment continuously throughout their lifetime? A 20-year longitudinal study. Psychol Med 42:2145-55
Goldberg, Joseph F; Harrow, Martin (2011) A 15-year prospective follow-up of bipolar affective disorders: comparisons with unipolar nonpsychotic depression. Bipolar Disord 13:155-63
Burdick, K E; Goldberg, J F; Harrow, M (2010) Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up. Acta Psychiatr Scand 122:499-506
Shankman, Stewart A; Nelson, Brady D; Harrow, Martin et al. (2010) Does physical anhedonia play a role in depression? A 20-year longitudinal study. J Affect Disord 120:170-6

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