Abstract

The aim of these investigations is to examine the role of the dopamine (DA) system in brain in relation to the etiology, pathogenesis, and treatment of psychotic disorders. Schizophrenia and related disorders including schizophreniform disorders associated with psychotogenic drug abuse are the ultimate targets of these studies. The approach involves both pre-clinical and clinical work. In preclinical experiments the action of known and potential psychotogenic compounds upon the DA system will be studied in rats by measurement of regional concentrations of DA metabolites. In clinical work, the use of plasma catecholamine metabolites as indicators of the course of neuroleptic treatment will be pursued. The relationship between neurochemical markers of the DA system, the hypophyseal-pituitary-adrenal axis, and clinical measures of stress will be a major focus of these studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH028216-18
Application #
3375022
Study Section
Special Emphasis Panel (SRCM (16))
Project Start
1979-05-01
Project End
1995-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
18
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Mazure, C M; Quinlan, D M; Bowers Jr, M B (1997) Recent life stressors and biological markers in newly admitted psychotic patients. Biol Psychiatry 41:865-70
Davis, M; Hitchcock, J M; Bowers, M B et al. (1994) Stress-induced activation of prefrontal cortex dopamine turnover: blockade by lesions of the amygdala. Brain Res 664:207-10
Bowers Jr, M B; Mazure, C M; Greenfeld, D G (1994) Elevated plasma monoamine metabolites in eating disorders. Psychiatry Res 52:11-5
Bowers Jr, M B; Morton, J B (1994) Regional brain catecholamines and metabolites following THC, PCP and MK-801. Prog Neuropsychopharmacol Biol Psychiatry 18:961-4
Bowers Jr, M B (1993) Psychotic patients with increased plasma HVA and MHPG or increased HVA alone. Biol Psychiatry 34:584-6
Bowers Jr, M B; Mazure, C M; Nelson, J C et al. (1992) Lithium in combination with perphenazine: effect on plasma monoamine metabolites. Biol Psychiatry 32:1102-7
Mazure, C M; Nelson, J C; Jatlow, P I et al. (1992) Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Res 41:147-54
Bowers Jr, M B; Morton, J B (1992) Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists. Prog Neuropsychopharmacol Biol Psychiatry 16:211-5
Bowers Jr, M B; Hoffman Jr, F J; Morton, J B (1991) Diazepam and haloperidol. Effect on regional brain homovanillic acid levels. Neuropsychopharmacology 5:65-9
Bowers Jr, M B (1991) Characteristics of psychotic inpatients with high or low HVA levels at admission. Am J Psychiatry 148:240-3

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