While even a single episode of depression is disabling and entails considerable economic loss and emotional suffering, recurrent depression represents a major public health problem. Effective treatments are available for the acute episode of depression, but relatively few clinical trials have been conducted on the maintenance treatment or prevention of subsequent episodes. Until now, maintenance treatment for recurrent unipolar depression has focused exclusively on the implementation of somatic therapies with only moderate success. We have over the last four years begun an investigation of psychological and combined treatments in comparison with somatic treatments alone. During the next five years, we expect to achieve the following major research goals: 1) to determine whether active, long-term (3 year) drug treatment (imipramine in combination with psychotherapy (Maintenance Interpersonal Psychotherapy) is superior to active drug treatment alone or psychotherapy alone or in combination with placebo (ongoing Study I); 2) to determine whether patients who do experience a recurrence or illness in a non-medication condition (i.e. no pill or placebo) in Study I, require 100% of their acute treatment dose or can be successfully maintained on 50% of that dose (Study II); 3) to ascertain whether those patients who survive three years of maintenance treatment in Study I without a recurrence can then be withdrawn from medicatIon without experiencing an recurrence in the subsequent two years (Study III); 4) to ascertain whether changes in selected biological, psychosocial, and clinical signs precede or are associated with recurrence of illness in unipolar patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH029618-13
Application #
3375118
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1977-06-01
Project End
1992-04-30
Budget Start
1990-04-01
Budget End
1992-04-30
Support Year
13
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Brindle, Ryan C; Duggan, Katherine A; Cribbet, Matthew R et al. (2018) Cardiovascular Stress Reactivity and Carotid Intima-Media Thickness: The Buffering Role of Slow-Wave Sleep. Psychosom Med 80:301-306
Brindle, Ryan C; Cribbet, Matthew R; Samuelsson, Laura B et al. (2018) The Relationship Between Childhood Trauma and Poor Sleep Health in Adulthood. Psychosom Med 80:200-207
Hall, Martica H; Mulukutla, Suresh; Kline, Christopher E et al. (2017) Objective Sleep Duration Is Prospectively Associated With Endothelial Health. Sleep 40:
Kline, Christopher E; Krafty, Robert T; Mulukutla, Suresh et al. (2017) Associations of sedentary time and moderate-vigorous physical activity with sleep-disordered breathing and polysomnographic sleep in community-dwelling adults. Sleep Breath 21:427-434
Sylvia, Louisa G; Salcedo, Stephanie; Peters, Amy T et al. (2017) Do Sleep Disturbances Predict or Moderate the Response to Psychotherapy in Bipolar Disorder? J Nerv Ment Dis 205:196-202
Stange, Jonathan P; Sylvia, Louisa G; da Silva Magalhães, Pedro Vieira et al. (2016) Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment. Br J Psychiatry 208:352-8
Levenson, Jessica C; Wallace, Meredith L; Anderson, Barbara P et al. (2015) Social rhythm disrupting events increase the risk of recurrence among individuals with bipolar disorder. Bipolar Disord 17:869-79
Peters, A; Sylvia, L G; Magalhães, P V da Silva et al. (2014) Age at onset, course of illness and response to psychotherapy in bipolar disorder: results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Psychol Med 44:3455-67
Deckersbach, Thilo; Peters, Amy T; Sylvia, Louisa et al. (2014) Do comorbid anxiety disorders moderate the effects of psychotherapy for bipolar disorder? Results from STEP-BD. Am J Psychiatry 171:178-86
Stange, Jonathan P; Sylvia, Louisa G; Magalhães, Pedro Vieira da Silva et al. (2013) Extreme attributions predict transition from depression to mania or hypomania in bipolar disorder. J Psychiatr Res 47:1329-36

Showing the most recent 10 out of 164 publications