Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
7R01MH033443-11
Application #
3375409
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1990-03-01
Project End
1992-06-30
Budget Start
1990-03-01
Budget End
1990-06-30
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of South Florida
Department
Type
Schools of Medicine
DUNS #
City
Tampa
State
FL
Country
United States
Zip Code
33612
Anandatheerthavarada, H K; Williams, J F; Wecker, L (1993) Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1. Biochem Biophys Res Commun 194:312-8
Coutcher, J B; Cawley, G; Wecker, L (1992) Dietary choline supplementation increases the density of nicotine binding sites in rat brain. J Pharmacol Exp Ther 262:1128-32
Zawia, N; Arendash, G W; Wecker, L (1992) Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain. Brain Res 589:333-7
Welsh, B; Wecker, L (1991) Effects of streptozotocin-induced diabetes on acetylcholine metabolism in rat brain. Neurochem Res 16:453-60
Wecker, L (1991) The synthesis and release of acetylcholine by depolarized hippocampal slices is increased by increased choline available in vitro prior to stimulation. J Neurochem 57:1119-27
Wecker, L (1990) Dietary choline: a limiting factor for the synthesis of acetylcholine by the brain. Adv Neurol 51:139-45
Miller, L G; Greenblatt, D J; Roy, R B et al. (1989) Dietary choline intake modulates benzodiazepine receptor binding and gamma-aminobutyric acidA receptor function in mouse brain. J Pharmacol Exp Ther 248:1-6
Wecker, L; Cawley, G; Rothermel, S (1989) Acute choline supplementation in vivo enhances acetylcholine synthesis in vitro when neurotransmitter release is increased by potassium. J Neurochem 52:568-75
Wecker, L (1988) Influence of dietary choline availability and neuronal demand on acetylcholine synthesis by rat brain. J Neurochem 51:497-504
Wuarin-Bierman, L; Wecker, L (1988) Choline supplementation increases serum alkaline phosphatase activity in rats. Clin Chim Acta 176:237-8

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