Abstract

This is a longitudinal study combined with cross-sectional studies of ADDH boys, normal boys, ADDH girls, and normal girls. Longitudinally, we will study three groups of boys, two with childhood ADDH disorders (ADDH-CD and ADDH-NCD) and normal control boys. Cross-sectionally, we will study 1) ADDH and normal six- year-old girls and 2) ADDH and normal eight-year-old boys. Full- field topography and a standardized electrode montage (International 10-20 system) will be used. We will compare the ERP patterns from two different modalities. We will study the effect of age on ERP and EEG measures. We will also study the effect of attention on ERP measures (Nd, P3) as a function of age, and we will study the effect of stimulant drugs on ERP and EEG measures in ADDH children as a function of age. Adult ERP and EEG data obtained from delinquent and nondelinquent adults who were formerly ADDH children will be available for comparison with our childhood data. The childhood ADDH syndrome is an important public health problem due to its prevalence, the lack of evidence that treatment in childhood affects long-term outcome, and the resulting (mainly untreatable) adolescent and adult psychopathological conditions, such as Conduct Disorder, Antisocial Personality Disorder, delinquency, and adult criminality.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH037344-08
Application #
3376166
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1982-09-15
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
California Child Study Foundation
Department
Type
DUNS #
City
Encino
State
CA
Country
United States
Zip Code
91316

  Publications

Satterfield, James H; Faller, Katherine J; Crinella, Francis M et al. (2007) A 30-year prospective follow-up study of hyperactive boys with conduct problems: adult criminality. J Am Acad Child Adolesc Psychiatry 46:601-10
Satterfield, J; Swanson, J; Schell, A et al. (1994) Prediction of antisocial behavior in attention-deficit hyperactivity disorder boys from aggression/defiance scores. J Am Acad Child Adolesc Psychiatry 33:185-90
Satterfield, J H; Schell, A M; Nicholas, T (1994) Preferential neural processing of attended stimuli in attention-deficit hyperactivity disorder and normal boys. Psychophysiology 31:1-10
Satterfield, J H; Schell, A M; Nicholas, T W et al. (1990) Ontogeny of selective attention effects on event-related potentials in attention-deficit hyperactivity disorder and normal boys. Biol Psychiatry 28:879-903
Satterfield, J H; Schell, A M; Nicholas, T et al. (1988) Topographic study of auditory event-related potentials in normal boys and boys with attention deficit disorder with hyperactivity. Psychophysiology 25:591-606
Satterfield, J H; Satterfield, B T; Schell, A M (1987) Therapeutic interventions to prevent delinquency in hyperactive boys. J Am Acad Child Adolesc Psychiatry 26:56-64