Forty off-medication patients with schizophrenia will receive 18F2-deoxyglucose (2DG) while executing the Continuous Performance Task (CPT), a psychophysical attention assessment. Simultaneous 32-channel topographic evoked potentials (EPs) to CPT stimuli will be obtained. Following uptake of 2DG and labeling of brain structures in the psychophysiological laboratory, the Neuroecat Scanner will obtain slice images with 7.6-7.8 mm in plane and 11.6-12.2 axial resolution assess the metabolic rate of glucose. The 40 patients will be obtained from the Clinical Research Centers of UCLA. Sixteen patients will have adult onset of symptoms (age 18 or later) and sixteen will have childhood onset (age 10 or earlier) but will be currently age 15 or older. The patients will be prescreened for CPT performance and will be selected for extremely poor or good CPT performance. Eight additional adult patients with intermediate CPT scores will allow analysis of positive/negative subtypes. This provides a 2X2 cell design, adult/childhood onset, good/poor attention (n=8 in each of four cells) for within patient group contrasts. Four groups of 16 normal age-and sex-matched normal volunteers will serve as contrasts. The first will be additionally matched on CPT performance to the 16 good attention patients. The second will be naive to CPT instructions and will be asked only to use the stimuli as a fixation point. The third sample will have CPT task difficulty adjusted so that their performance matches the poor schizophrenics. The fourth will only press a button at 4 second intervals. PET images will be converted to units of micromoles glucose/100g/minute and analyzed quantitatively. Analyses will identify specific structures by reference to magnetic resonance scans. A second analysis will examine cortical surface activity obtained from our 3-D reconstruction technique and correlate this with regional evoked potential techniques. In our initial studies with PET, we found schizophrenics to have a diminished anteroposterior metabolic rate gradient with occipital and parietal areas showing higher rates than normal. The current study extends this work using PET with higher resolution, a cognitive task of widely demonstrated salience, topographic EPs covering both hemispheres, and NMR scans to identify anatomic landmarks with greater accuracy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH040071-02
Application #
3377987
Study Section
(SRCM)
Project Start
1986-03-01
Project End
1988-02-29
Budget Start
1987-03-01
Budget End
1988-02-29
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Hazlett, Erin A; Byne, William; Brickman, Adam M et al. (2010) Effects of sex and normal aging on regional brain activation during verbal memory performance. Neurobiol Aging 31:826-38
Hazlett, Erin A; Buchsbaum, Monte S; Haznedar, M Mehmet et al. (2008) Cortical gray and white matter volume in unmedicated schizotypal and schizophrenia patients. Schizophr Res 101:111-23
Buchsbaum, Monte S; Buchsbaum, Bradley R; Hazlett, Erin A et al. (2007) Relative glucose metabolic rate higher in white matter in patients with schizophrenia. Am J Psychiatry 164:1072-81
Mitelman, Serge A; Byne, William; Kemether, Eileen M et al. (2006) Correlations between volumes of the pulvinar, centromedian, and mediodorsal nuclei and cortical Brodmann's areas in schizophrenia. Neurosci Lett 392:16-21
Brickman, Adam M; Buchsbaum, Monte S; Ivanov, Zlatin et al. (2006) Internal capsule size in good-outcome and poor-outcome schizophrenia. J Neuropsychiatry Clin Neurosci 18:364-76
Mitelman, Serge A; Byne, William; Kemether, Eileen M et al. (2006) Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumes. Brain Res 1114:125-37
Haznedar, M Mehmet; Buchsbaum, Monte S; Hazlett, Erin A et al. (2006) Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders. Am J Psychiatry 163:1252-63
Mitelman, Serge A; Shihabuddin, Lina; Brickman, Adam M et al. (2005) Cortical intercorrelations of temporal area volumes in schizophrenia. Schizophr Res 76:207-29
Mitelman, Serge A; Byne, William; Kemether, Eileen M et al. (2005) Metabolic disconnection between the mediodorsal nucleus of the thalamus and cortical Brodmann's areas of the left hemisphere in schizophrenia. Am J Psychiatry 162:1733-5
Hazlett, Erin A; New, Antonia S; Newmark, Randall et al. (2005) Reduced anterior and posterior cingulate gray matter in borderline personality disorder. Biol Psychiatry 58:614-23

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