We request support for continuation of the Copenhagen High Risk Project. In 1962 we intensively examined a group (N=207) of offspring of schizophrinic women (HR offspring) and matched Low Risk (LR, N=104) controls. In the ensuing 26 years we have completed several reassessments of the HR and LR samples, including diagnostic interviews, psychological examinations and CT-scans (for a subgroup). In 1972 we completed an intensive diagnostic interview which ascertained 15 schizophrenics and 29 schizotypals in the HR group. We have published a number of papers which have described environmental and qenetic precursors of the schizophrenic and spectrum illnesses of these individuals. We have also been able to delineate differential environmental factors associated with predominantly positive and predominantly negative symptom subtypes. We are currently completing an intensive diagnostic assessment of the HR and LR samples to achieve a lifetime diagnosis, as well as CT scans and smooth pursuit eye movement examinations. This examination will be complete and diagnoses assigned by February, 1989; we anticipate identifying an additional 15-17 schizophrenics. Support is being requested for the extensive data analysis of the total data bank. It is our intention to attempt to replicate the results of the earlier analyses relating to the precursors of schizophrenia, the spectrum disorders as well as the positive and negative symptom subtypes. We also will examine new hypotheses regarding gene-environment interactions in the development of schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH041469-05
Application #
3380090
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1986-05-01
Project End
1991-08-31
Budget Start
1990-09-01
Budget End
1991-08-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Thygesen, Johan Hilge; Zambach, Sine Katharina; Ingason, Andrés et al. (2015) Linkage and whole genome sequencing identify a locus on 6q25-26 for formal thought disorder and implicate MEF2A regulation. Schizophr Res 169:441-446
Raballo, Andrea; Parnas, Josef (2011) The silent side of the spectrum: schizotypy and the schizotaxic self. Schizophr Bull 37:1017-26
Raballo, Andrea; Saebye, Ditte; Parnas, Josef (2011) Looking at the schizophrenia spectrum through the prism of self-disorders: an empirical study. Schizophr Bull 37:344-51
Vaever, Mette S; Licht, Deborah M; Moller, Lise et al. (2005) Thinking within the spectrum: schizophrenic thought disorder in six Danish pedigrees. Schizophr Res 72:137-49
Higgins, J; Gore, R; Gutkind, D et al. (1997) Effects of child-rearing by schizophrenic mothers: a 25-year follow-up. Acta Psychiatr Scand 96:402-4
LaFosse, J M; Mednick, S A; Praestholm, J et al. (1994) The influence of parental socioeconomic status on CT studies of schizophrenia. Schizophr Res 11:285-90
Hollister, J M; Mednick, S A; Brennan, P et al. (1994) Impaired autonomic nervous system-habituation in those at genetic risk for schizophrenia. Arch Gen Psychiatry 51:552-8
Parnas, J; Cannon, T D; Jacobsen, B et al. (1993) Lifetime DSM-III-R diagnostic outcomes in the offspring of schizophrenic mothers. Results from the Copenhagen High-Risk Study. Arch Gen Psychiatry 50:707-14
Cannon, T D; Mednick, S A; Parnas, J (1990) Antecedents of predominantly negative- and predominantly positive-symptom schizophrenia in a high-risk population. Arch Gen Psychiatry 47:622-32
Parnas, J; Jorgensen, A; Teasdale, T W et al. (1988) Temporal course of symptoms and social functioning in relapsing schizophrenics: a 6-year follow-up. Compr Psychiatry 29:361-71

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