Although family, twin, and adoption studies indicate that heredity plays a role in manic-depression (MDI) and schizophrenia, the genetic factors involved or their mode of inheritance remains unknown. Important advances in molecular biology over the past decade now make it possible to determine the approximate chromosomal location of the gene(s) that may play a role in these illnesses. Toward this goal, identifying multigenerational families afflicted with MDI and schizophrenia is crucial. We have identified several such families and are searching for others. Permanent cell lines are being established and DNA processed for restriction endonuclease mapping. As a result of this project, the etiology, genetics, and treatment of MDI and schizophrenia may be better understood.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042643-02
Application #
3381879
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1988-06-01
Project End
1991-05-31
Budget Start
1989-06-01
Budget End
1990-05-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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