Recent evidence from the study of behavioral genetics has underscored the importance of the different or nonshared environments of siblings within the family. These data emphasize that it is these within family differences which are the most likely sources of non-genetic influence on both normal and pathological development in children and adolescents. This proposal focuses on the nonshared family environment which may contribute to the pathogenesis of psychopathology as well as the development of competence in adolescents using a novel step- family design. Step-families, depending on their form contains siblings who vary in genetic relationships from 50% for full sibs, to 25% for half sibs to 0% for blended sibs. This variation permits an estimate of which effects of the nonshared enviornment are genetically mediated and which are not. The design calls for a random and representative sample of 600 step-families equally divided into full, half, and blended sib types and a comparably sampled control group of 200 non-divorced families. Measures of the nonshared environment will include assessments of marital, parent-child, sibling, friendship and whole-family relationships. Of particular importance will be measurement by direct observation of family process and child behavior permitting an unusually precise estimate of both genetic and family interaction processes. Dependent measures will use current assessment procedures for conduct disorder and depression in adolescents as well as assessment of areas of competent development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH043373-03
Application #
3382869
Study Section
(SRCM)
Project Start
1987-09-30
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
George Washington University
Department
Type
Schools of Medicine
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052
Marceau, Kristine; Knopik, Valerie S; Neiderhiser, Jenae M et al. (2016) Adolescent age moderates genetic and environmental influences on parent-adolescent positivity and negativity: Implications for genotype-environment correlation. Dev Psychopathol 28:149-66
Neiderhiser, Jenae M; Marceau, Kristine; Reiss, David (2013) Four factors for the initiation of substance use by young adulthood: a 10-year follow-up twin and sibling study of marital conflict, monitoring, siblings, and peers. Dev Psychopathol 25:133-49
Marceau, Kristine; Horwitz, Briana N; Narusyte, Jurgita et al. (2013) Gene-environment correlation underlying the association between parental negativity and adolescent externalizing problems. Child Dev 84:2031-46
Marceau, Kristine; Humbad, Mikhila N; Burt, S Alexandra et al. (2012) Observed externalizing behavior: a developmental comparison of genetic and environmental influences across three samples. Behav Genet 42:30-9
Rasbash, Jon; Jenkins, Jennifer; O'Connor, Thomas G et al. (2011) A social relations model of observed family negativity and positivity using a genetically informative sample. J Pers Soc Psychol 100:474-91
Ge, Xiaojia; Natsuaki, Misaki N; Neiderhiser, Jenae M et al. (2009) The longitudinal effects of stressful life events on adolescent depression are buffered by parent-child closeness. Dev Psychopathol 21:621-35
Natsuaki, Misaki N; Ge, Xiaojia; Reiss, David et al. (2009) Aggressive behavior between siblings and the development of externalizing problems: evidence from a genetically sensitive study. Dev Psychol 45:1009-18
Burt, S Alexandra; Neiderhiser, Jenae M (2009) Aggressive versus nonaggressive antisocial behavior: distinctive etiological moderation by age. Dev Psychol 45:1164-76
Harakeh, Zeena; Neiderhiser, Jenae M; Spotts, Erica L et al. (2008) Genetic factors contribute to the association between peers and young adults smoking: univariate and multivariate behavioral genetic analyses. Addict Behav 33:1113-22
Dimas, Christos; Reiss, David; Neiderhiser, Jenae (2008) Summaries of the Sixth Annual Poster Session of the American Psychoanalytic Association: part I. Triangular relationships in adolescence predict adult psychopathology: an empirical validation of the Oedipus complex? J Am Psychoanal Assoc 56:1342-8

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