A unique group of 175 patients experiencing their first lifetime episode of psychosis has been gather. And an attempt was made to recruit every case of first-episode psychosis that appeared in metropolitan Vancouver, Canada, over a two and one half year time span. The project focus was on psychosocial and biological factors associated with schizophrenia and the course of illness. Follow-up data are available at 9 months, 18 months, and then 5 years after initial illness. The data include measures that tap an array of psychosocial characteristics, putative psychophysiological markers of genetic vulnerability to schizophrenia, brain morphology, family history, premorbid personality, treatment history, and detailed clinical diagnostic data. Comparative data are available on a group of normal control subjects (n =141) recruited from the same community. To evaluate the potential of the psychophysiological measures as markers of schizophrenia, all available first-degree relatives of the first-episode psychotic patients and the normal subjects were also recruited. There is no data set comparable to this anywhere else and it is unlikely to replicated. While a number of publications have emerged based on this study, the rich data provide exciting opportunities to explore the interaction between biological and psychosocial factors in predicting the course of a baffling, disabling, and socially wasteful illness.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH044643-01A1
Application #
3384017
Study Section
Epidemiologic and Services Research Review Committee (EPS)
Project Start
1989-09-01
Project End
1991-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Arts and Sciences
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Katsanis, J; Iacono, W G; Beiser, M (1996) Eye-tracking performance and adaptive functioning over the short-term course of first-episode psychosis. Psychiatry Res 64:19-26
Husted, J A; Beiser, M; Iacono, W G (1995) Negative symptoms in the course of first-episode affective psychosis. Psychiatry Res 56:145-54
Zhang-Wong, J; Beiser, M; Bean, G et al. (1995) Five-year course of schizophreniform disorder. Psychiatry Res 59:109-17
Clementz, B A; Iacono, W G; Beiser, M (1994) Handedness in first-episode psychotic patients and their first-degree biological relatives. J Abnorm Psychol 103:400-3
Clementz, B A; Sponheim, S R; Iacono, W G et al. (1994) Resting EEG in first-episode schizophrenia patients, bipolar psychosis patients, and their first-degree relatives. Psychophysiology 31:486-94
Sponheim, S R; Clementz, B A; Iacono, W G et al. (1994) Resting EEG in first-episode and chronic schizophrenia. Psychophysiology 31:37-43
Feil, K J; Iacono, W G; Grove, W M (1994) Effect of chronic alcohol use on smooth pursuit eye movements. Psychiatry Res 52:99-101
Beiser, M; Bean, G; Erickson, D et al. (1994) Biological and psychosocial predictors of job performance following a first episode of psychosis. Am J Psychiatry 151:857-63
Gooding, D C; Iacono, W G; Beiser, M (1994) Temporal stability of smooth-pursuit eye tracking in first-episode psychosis. Psychophysiology 31:62-7
Iacono, W G; Clementz, B A (1993) A strategy for elucidating genetic influences on complex psychopathological syndromes (with special reference to ocular motor functioning and schizophrenia). Prog Exp Pers Psychopathol Res 16:11-65

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