The purpose of this study is to examine whether measures of increased noradrenergic activity in haloperidol treated schizophrenic patients predicts relapse following drug withdrawal. Establishing predictors of rapid relapse following neuroleptic discontinuance will be important in targeted or intermittent neuroleptic treatment. One hundred carefully diagnosed, physically healthy, male schizophrenics will be recruited for the study. Subjects will be clinically stabilized on oral haloperidol prior to entering the study. After giving consent, each subject will receive a standard diet, and be evaluated with rating scales, as well as a series of biological measures related to noradrenergic function (three consecutive 24 hour urines for norepinephrine (NE), 3-methoxy-4-hydroxyphenolglycol (MHPG), vanillyl mandlic acid (VMA), normetanephrine (NM); a lumbar puncture for CSF NE and MHPG; and an intravenous clonidine challenge test to measure the plasma growth hormone (GH) and MHPG response). Subjects will then be withdrawn from haloperidol and followed as outpatients until relapse or for one year if they remain clinically stable. Patients will be assessed weekly to determine relapse and clinical stability. Data will be analyzed to test the hypothesis that noradrenergic variables measured during haloperidol maintenance treatment are predictors of subject's time to relapse. """"""""Survival"""""""" analysis (Cox regression) will be used. This method of data analysis permits factors such as age, duration of illness, haloperidol blood levels, tardive dyskinesia, and the presence of brain atrophy to be considered.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH044841-03
Application #
3384338
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Condray, Ruth; Yao, Jeffrey K; Steinhauer, Stuart R et al. (2008) Semantic memory in schizophrenia: association with cell membrane essential fatty acids. Schizophr Res 106:13-28
Kelley, Mary E; Haas, Gretchen L; van Kammen, Daniel P (2008) Longitudinal progression of negative symptoms in schizophrenia: a new look at an old problem. Schizophr Res 105:188-96
Allen, Daniel N; Frantom, Linda V; Strauss, Gregory P et al. (2005) Differential patterns of premorbid academic and social deterioration in patients with schizophrenia. Schizophr Res 75:389-97
Yao, Jeffrey K; van Kammen, Daniel P (2004) Membrane phospholipids and cytokine interaction in schizophrenia. Int Rev Neurobiol 59:297-326
Yao, J K; Sistilli, C G; van Kammen, D P (2003) Membrane polyunsaturated fatty acids and CSF cytokines in patients with schizophrenia. Prostaglandins Leukot Essent Fatty Acids 69:429-36
Allen, D N; Kelley, M E; Miyatake, R K et al. (2001) Confirmation of a two-factor model of premorbid adjustment in males with schizophrenia. Schizophr Bull 27:39-46
Yao, J K; Reddy, R D; van Kammen, D P (2001) Oxidative damage and schizophrenia: an overview of the evidence and its therapeutic implications. CNS Drugs 15:287-310
Allen, D N; Goldstein, G; Forman, S D et al. (2000) Neurologic examination abnormalities in schizophrenia with and without a history of alcoholism. Neuropsychiatry Neuropsychol Behav Neurol 13:184-7
Allen, D N; Seaton, B E; Goldstein, G et al. (2000) Neuroanatomic differences among cognitive and symptom subtypes of schizophrenia. J Nerv Ment Dis 188:381-4
Allen, D N; Anastasiou, A; Goldstein, G et al. (2000) Influence of haloperidol on the relationship of frontal lobe function to psychomotor poverty and disorganization syndromes. Psychiatry Res 93:33-9

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