Schizophrenia is a relatively frequent and disabling disease of variable expression and unknown, but perhaps heterogeneous cause. Definition of subtypes and pathogenesis-symptom complex relationships are prerequisites to advances in therapeutics and prevention. The objective of our research is to test the hypothesis of heterogeneity by searching for genetically validated subtypes. To this end, we have collected from an epidemiologic sample, a large number of families with more than on affected member. We now propose a genetic study of these families using recombinant DNA methods. In addition to candidate gene and chromosome specific probes, we will use cytogenetic and biochemical polymorphisms to look for linkages and associations which will suggest areas of specific chromosomes to examine with relevant probes. Associations of clinical expression with specific genes would form a useful basis for a classification of the types of schizophrenia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH045588-04
Application #
2246677
Study Section
Special Emphasis Panel (SRCM)
Project Start
1989-02-01
Project End
1995-06-30
Budget Start
1992-03-01
Budget End
1995-06-30
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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