Abstract

Our goal is to characterize high energy phosphorus and phospholipid metabolism of the brain in HIV disease. We will utilize in vivo Magnetic Resonance Spectroscopy (MRS) to study HIV seropositive patients who range from normal neuropsychiatric function to full-blown AIDS Demential Complex (ADC). In our pilot study, we found a decrease in the adenosine triphosphate (ATP) in inorganic phosphate (Pi) and phosphocreatine (PCr) to Pi ratios in HIV-infected patients (mostly AIDS/ARC) compared to control subjects and a negative correlation between ratios and degree of neuropsychiatric impairment within the patient group. We will determine whether MRS measures of in vivo brain phosphors and phospholipid metabolism differ in HIV infected individuals compared to HIV negative controls and if HIV related changes in these measures are associated with the presence and/or degree of neuropsychiatric impairments. We will also determine whether the in vivo brain metabolic changes associated with ADC are specific to ADC or are general findings reflective of subcortical dementia and if particular in vivo brain metabolic changes in ADC are specific to white matter or subcortical grey matter. Finally we will determine whether changes in neuropsychiatric status in HIV disease (either as a result of disease progression or positive treatment response) are associated with changes in MRS measures of phosphorus and phospholipid metabolism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH045680-02
Application #
3385496
Study Section
MH Acquired Immunodeficiency Syndrome Research Review Committee (MHAZ)
Project Start
1990-04-01
Project End
1993-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Nielsen-Bohlman, Lynn; Fein, George; Boyle, Devon et al. (2002) N400 event-related potential reduction indexes: early central nervous system impairment in HIV. J NeuroAIDS 2:51-65
Di Sclafani, V; Mackay, R D; Meyerhoff, D J et al. (1997) Brain atrophy in HIV infection is more strongly associated with CDC clinical stage than with cognitive impairment. J Int Neuropsychol Soc 3:276-87
Nielsen-Bohlman, L; Boyle, D; Biggins, C et al. (1997) Semantic priming impairment in HIV. J Int Neuropsychol Soc 3:348-58
Meyerhoff, D J; Weiner, M W; Fein, G (1996) Deep gray matter structures in HIV infection: a proton MR spectroscopic study. AJNR Am J Neuroradiol 17:973-8
MacKay, S; Meyerhoff, D J; Constans, J M et al. (1996) Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging. Arch Neurol 53:167-74
Constans, J M; Meyerhoff, D J; Gerson, J et al. (1995) H-1 MR spectroscopic imaging of white matter signal hyperintensities: Alzheimer disease and ischemic vascular dementia. Radiology 197:517-23
Fein, G; Biggins, C A; MacKay, S (1995) Alcohol abuse and HIV infection have additive effects on frontal cortex function as measured by auditory evoked potential P3A latency. Biol Psychiatry 37:183-95
Constans, J M; Meyerhoff, D J; Norman, D et al. (1995) 1H and 31P magnetic resonance spectroscopic imaging of white matter signal hyperintensity areas in elderly subjects. Neuroradiology 37:615-23
Fein, G; Biggins, C A; MacKay, S (1995) Delayed latency of the event-related brain potential P3A component in HIV disease. Progressive effects with increasing cognitive impairment. Arch Neurol 52:1109-18
Meyerhoff, D J; MacKay, S; Sappey-Marinier, D et al. (1995) Effects of chronic alcohol abuse and HIV infection on brain phosphorus metabolites. Alcohol Clin Exp Res 19:685-92

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