Attention-deficit hyperactivity disorder (ADHD) is defined by symptoms of inattention, impulsivity and hyperactivity, but the existence of all three concurrently is not required for a diagnosis. ADHD children also differ in associated features, such as the presence of aggressive behavior or cognitive deficits, and have disparate long-term outcomes. Due in part to this heterogeneity, diagnostic validity for ADHD has not been established, and as a result, it has been impossible to isolate the etiologic and prognostic determinants of this extremely prevalent disorder. It is proposed that ADHD is not a unitary or a valid syndrome, but rather, that two distinct groups of ADHD children can be identified based upon the presence o absence of aggressive behavior. It is hypothesized that non- aggressive ADHD children will comprise an Inattentive/Cognitively Impaired group characterized by inattention, impulsivity, cognitive deficits, and evidence of increased noradrenergic metabolism; and aggressive ADHD children will comprise an Impulsive/Aggressive group characterized by impulsivity, in the absence of inattention and cognitive problems, and evidence of reduced central serotonergic function and noradrenergic metabolism. The goal is to establish the concurrent validity of the diagnostic distinctions between these two groups of ADHD children. Three groups of 30 boys will participate in this research: aggressive ADHD boys, non-aggressive ADHD, and normal controls. The three groups will be compared on neuropsychological measures of attention, impulse control, and learning. The two patient groups will be compared on neurobiological measures of noradrenergic and serotonergic functioning.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH046448-02
Application #
3386259
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1990-08-01
Project End
1993-07-31
Budget Start
1991-08-01
Budget End
1992-07-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Queens College
Department
Type
Schools of Arts and Sciences
DUNS #
City
Flushing
State
NY
Country
United States
Zip Code
11367
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Harty, Seth C; Galanopoulos, Stavroula; Newcorn, Jeffrey H et al. (2013) Delinquency, aggression, and attention-related problem behaviors differentially predict adolescent substance use in individuals diagnosed with ADHD. Am J Addict 22:543-50
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Nomura, Yoko; Marks, David J; Halperin, Jeffrey M (2010) Prenatal exposure to maternal and paternal smoking on attention deficit hyperactivity disorders symptoms and diagnosis in offspring. J Nerv Ment Dis 198:672-8
Bédard, Anne-Claude V; Trampush, Joey W; Newcorn, Jeffrey H et al. (2010) Perceptual and motor inhibition in adolescents/young adults with childhood-diagnosed ADHD. Neuropsychology 24:424-34
Harty, Seth C; Miller, Carlin J; Newcorn, Jeffrey H et al. (2009) Adolescents with childhood ADHD and comorbid disruptive behavior disorders: aggression, anger, and hostility. Child Psychiatry Hum Dev 40:85-97
Halperin, Jeffrey M; Trampush, Joey W; Miller, Carlin J et al. (2008) Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls. J Child Psychol Psychiatry 49:958-66

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