Abstract

The proposed studies are designed to examine the neuropsychological processes underlying the deficits in stem-completion and paired-associate priming exhibited by patients with dementia of the Alzheimer type (DAT). Since such long-term priming is intact in patients with circumscribed amnesia and in patients with other forms of dementia,identification of the processes associated with the impaired priming in DAT may lead to information about the necessary and sufficient conditions for the priming phenomenon to occur. In addition, by examining the processes underlying the priming deficit in mildly demented DAT patients, the present project may provide the information about the clinical utility of the priming phenomenon for the differential diagnosis of DAT. The first set of experi-ments will examine the effect of semantic orienting tasks on the verbal priming of DAT patients. The relationship of vigilance, selective attention and arousal to the priming performance of DAT patients will be examined in the second set of experiments. A third set of experiments will examine the role of visuoperceptual processes in the priming deficit of DAT patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH048819-01
Application #
3388321
Study Section
Life Course and Prevention Research Review Committee (LCR)
Project Start
1992-03-01
Project End
1996-02-29
Budget Start
1992-03-01
Budget End
1993-02-28
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Rouleau, Isabelle; Salmon, David P; Vrbancic, Mirna (2002) Learning, retention and generalization of a mirror tracing skill in Alzheimer's disease. J Clin Exp Neuropsychol 24:239-50
Salmon, D P; Butters, N; Chan, A S (1999) The deterioration of semantic memory in Alzheimer's disease. Can J Exp Psychol 53:108-17
Heindel, W C; Salmon, D P; Fennema-Notestine, C et al. (1998) Repetition priming with nonverbal stimuli in patients with dementia of the Alzheimer type. Neuropsychology 12:43-51
Chan, A S; Butters, N; Salmon, D P (1997) The deterioration of semantic networks in patients with Alzheimer's disease: a cross-sectional study. Neuropsychologia 35:241-8
Heindel, W C; Cahn, D A; Salmon, D P (1997) Non-associative lexical priming is impaired in Alzheimer's disease. Neuropsychologia 35:1365-72
Peavy, G M; Salmon, D P; Rice, V A et al. (1996) Neuropsychological assessment of severely demeted elderly: the severe cognitive impairment profile. Arch Neurol 53:367-72
Taylor, K I; Salmon, D P; Rice, V A et al. (1996) Longitudinal examination of American National Adult Reading Test (AMNART) performance in dementia of the Alzheimer type (DAT): validation and correction based on degree of cognitive decline. J Clin Exp Neuropsychol 18:883-91
Salmon, D P; Galasko, D; Hansen, L A et al. (1996) Neuropsychological deficits associated with diffuse Lewy body disease. Brain Cogn 31:148-65
Rouleau, I; Salmon, D P; Butters, N (1996) Longitudinal analysis of clock drawing in Alzheimer's disease patients. Brain Cogn 31:17-34
Salmon, D P; Butters, N (1995) Neurobiology of skill and habit learning. Curr Opin Neurobiol 5:184-90

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